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myeloid cells

GOLM1 Exacerbates CD8+ T Cell Suppression in Hepatocellular Carcinoma by Promoting Exosomal PD-L1 Transport into Tumor-Associated Macrophages

[Signal Transduction and Targeted Therapy] Golgi membrane protein 1 (GOLM1) was positively correlated with infiltrating tumor-associated macrophages expressed high levels of programmed death-ligand 1 (PD-L1) and CD8+ T cell suppression in hepatocellular carcinoma tissues.

Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway

[Hypertension] The role of the CCL5 and IL4 in kidney fibrosis was studied by administration of the CCL5 receptor antagonist maraviroc or by injections of an anti-IL4 neutralizing antibody.

The Effect of α7nAChR Signaling on T Cells and Macrophages and Their Clinical Implication in the Treatment of Rheumatic Diseases

[Neurochemical Research] Investigators summarize the roles of different T cells and macrophages subsets in the occurrence and progression of rheumatoid arthritis (RA), and highlighted the immune consequences of cholinergic anti-inflammatory pathway activation in these cells under RA circumstances.

VEGF-A, PDGF-BB and HB-EGF Engineered for Promiscuous Super Affinity to the Extracellular Matrix Improve Wound Healing in a Model of Type 1 Diabetes

[NPJ Regenerative Medicine] In the type 1 diabetic NOD mouse model, engineered growth factors improved both re-epithelialization and granulation tissue formation.

Requirement of Direct Contact between Chondrocytes and Macrophages for the Maturation of Regenerative Cartilage

[Scientific Reports] Researchers examined the host cells that promoted cartilage maturation via cell–cell contact. Based on analysis of the transplanted chondrocytes, they examined the contribution of endothelial cells and macrophages.

Inhibition of DTYMK Significantly Restrains the Growth of HCC and Increases Sensitivity to Oxaliplatin

[Cell Reports] The authors revealed that deoxythymidylate kinase (DTYMK) levels significantly increased and correlated with poor prognosis in hepatocellular carcinoma (HCC).

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