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myocytes

Control of Satellite Cell Function in Muscle Regeneration and Its Disruption in Aging

[Nature Reviews Molecular Cell Biology] Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. The authors discuss the role and regulation of satellite cells in skeletal muscle homeostasis and regeneration.

Collagen-Derived Dipeptide Pro-Hyp Administration Accelerates Muscle Regenerative Healing Accompanied by Less Scarring after Wounding on the Abdominal Wall in Mice

[Scientific Reports] Pro-Hyp administration induced many myogenically differentiated cells, including myogenin-positive myoblasts and myoglobin-positive myocytes, to migrate in the granulation tissue, while scar tissue decreased, indicating that Pro-Hyp administration accelerated muscle regenerative healing accompanied by less scarring after wounding on the abdominal wall.

Hemicentin-1 Is an Essential Extracellular Matrix Component of the Dermal–Epidermal and Myotendinous Junctions

[Scientific Reports] Performing in situ hybridization and immunofluorescence analysis, researchers found that mouse Hmcn1 and Hmcn2 showed a complementary distribution throughout different tissues and developmental stages.

The Hippo Pathway Regulates Density-Dependent Proliferation of iPSC-Derived Cardiac Myocytes

[Scientific Reports] The Hippo pathway regulates the proliferation of cancer cells, pluripotent stem cells, and epithelial cells through a cell–cell contact-dependent manner, however, it is unclear if cell density-dependent cell proliferation is a consistent feature in cardiac myocytes. Scientists used cultured human iPSC-derived cardiac myocytes as a model system to investigate this concept.

Hepatocyte-Derived Exosomes from Early Onset Obese Mice Promote Insulin Sensitivity through miR-3075

[Nature Metabolism] FA2H was a direct target of miR-3075 and small interfering RNA depletion of FA2H in adipocytes, myocytes and primary hepatocytes led to increased insulin sensitivity. In chronic obesity, hepatocyte exosomes promoted a state of insulin resistance.

Tissue-Engineered Esophagus: Recellular Esophageal Extracellular Matrix Based on Perfusion-Decellularized Technique and Mesenchymal Stem Cells

[Biomedical Materials] In this study, the esophageal extracellular matrix scaffold was successfully constructed by perfusion-decellularized technique through the vascular system for the first time.

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