neural cells

[Cell and Tissue Research] Data showed that thrombospondin-1 (Tsp-1) downregulation aggravated UV irradiation-induced DNA damage in 661 W cells and cone photoreceptor cells.

[Trends in Molecular Medicine] Investigators review the association between iron deposition, glial activation, and neuronal death, and discuss whether and how ferroptosis affects α-synuclein aggregation and dopaminergic neuron loss.

[NPG Asia Materials] Researchers developed gethacrylate gelatin (GelMA)/ECM hydrogel fibrous scaffolds that could recruit and enhance the differentiation of neural stem cells by electrospinning and decellularization techniques.

[Cancer Research] Researchers explored the potential of antisense oligonucleotides (ASO)-based pyruvate kinase (PKM) splice switching as a targeted therapy for liver cancer. A more potent lead constrained-ethyl/DNA ASO induced PKM splice switching and inhibited the growth of cultured HCC cells.

[Advanced Science] The authors reported a robust method to convert fibroblasts to neurons through targeting the cytoskeleton followed by exposure to lineage-specification surroundings.

[Biohaven Pharmaceutical Holding Company Ltd.] Biohaven Pharmaceutical Holding Company Ltd. announced that it entered into a license agreement with Bristol Myers Squibb for the development and commercialization rights to taldefgrobep alfa, a novel, Phase III-ready anti-myostatin adnectin.