neural cells

[Communications Biology] Researchers demonstrated that SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)Thr249 phosphorylation played an essential role in maintaining glioma stem cell (GSC) stemness and tumorigenicity. SMURF2 silencing augmented the self-renewal potential and tumorigenicity of patient-derived GSCs.

[Developmental Cell] F3-antibody-sorted glioblastoma cells exhibited stem cell gene expression, enhanced self-renewal in culture, drove tumor initiation and serial transplantation, and reconstituted tumor heterogeneity.

[Scientific Reports] The authors showed that the glial fibrillary acidic protein δ (GFAPδ) and GFAPα isoforms differentially regulated the tumor dynamics of glioma cells. Depletion of either isoform increased the migratory capacity of glioma cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists established a role of de novo lipogenesis for mouse and human brain development and identified a link between progenitor-cell polarity and lipid metabolism.

[Scientific Reports] Researchers aimed to find a relationship between the proteins coded by the most relevant genes associated with amyotrophic lateral sclerosis and intracellular Ca2+ accumulation.

[Cell Death Discovery] Scientists demonstrated the effects of amyloid precursor protein-derived C-terminal fragments (APP-CTFs)-related pathology using induced neural stem cells (iNSCs) from Alzheimer’s disease patient-derived fibroblasts.