neural cells

[Advanced Science] A proteome map of COVID-19 skin was established and the susceptibility of human-induced pluripotent stem cell-derived skin organoids with hair follicles and nervous system was investigated, to SARS-CoV-2 infection.

[Cell Death & Differentiation] Researchers demonstrated that a novel Olig2-binding protein, DEAD-box helicase 20 (Ddx20), was indispensable for the survival of neural progenitor cells and oligodendrocyte progenitor cells.

[Pediatric Research] Investigators observed high KIF5C expression in neurons during the early developmental stage in mice and the human brain. Kif5c deficiency resulted in disturbed cortical neuronal migration, dendritic, and spine growth.

[Proceedings of the National Academy of Sciences of the United States of America] The authors engineered the highly migratory and brain tumor tropic human neural stem cells LM008 to continuously secrete high amounts of functional, stable, full-length antibodies against human epidermal growth factor receptor 2 (HER2) without compromising the stemness of LM008 cells.

[Neurochemical Research] Researchers showed that epidermal growth factor (EGF) negatively regulated presynaptic maturation and synapse formation. In cortical neurons, EGF maintained axon elongation and reduced the sizes of growth cones in culture.

[Molecular Neurobiology] Using stable cell lines expressing alpha-synuclein, the authors examined the correlation between endogenous alpha-synuclein levels and the seeding propensity by exogenous alpha-synuclein preformed fibrils