neural cells

[Nature Communications] The engineered FailSafeTM hPSCs demonstrated robust ventral midbrain specification in vitro, capable of forming neural grafts upon transplantation.

[Scientific Reports] Researchers created neural progenitor cells (NPC) derived from individuals with chromosome 2q23.1 deletion and conducted RNA-seq to identify differentially expressed genes (DEGs) and the biological processes and pathways altered in MAND.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists described a multicenter effort to test the generality of this pivotal observation, using independent analyses at two laboratories of patient-derived and newly engineered human neurons with heterozygous NRXN1 deletions.

[Neuron] By performing unbiased transcriptional profiling of DMV cholinergic neurons, the authors discovered seven molecularly distinct subtypes of motor neurons.

[Stem Cell Reports] Scientists used isogenic human induced pluripotent stem cells (iPSCs) with and without PARK2 knockout to investigate the effect of parkin loss of function by comparative metabolomics supplemented with ultrastructural and functional analyses.

[International Journal of Molecular Sciences] The authors summarize the various roles of astrocytes in recruiting immune cells to lesion sites, engendering the inflammatory loop, and inflicting tissue damage.