neurons

[iScience] Investigators defined several features of circ-Hdgfrp3 and described interesting alterations occurring in motor neurons carrying ALS-associated FUS mutations. Through a highly sensitive in situ approach they described that circ-Hdgfrp3 trafficked along neurites, whilst upon oxidative stress it was retained in the perinuclear region.

[iScience] Through a combination of chemical proteomics, gel-based separation of modified and unmodified proteins and an activity assay, the authors determined that the modified, lysosomal soluble form of exonuclease PLD3 increased dramatically during neuronal maturation and that AMPylation correlated with its catalytic activity.

[Molecular Neurobiology] The authors analyze the various carriers that have been employed for the release of growth factors in an orderly fashion and their constituents, along with the advantages and the limitations they pose in delivering the growth factors for facilitating the process of neuronal transdifferentiation.

[Scientific Reports] Scientists analyzed the physiological role of Wdr45 and pathophysiological significance of the gene abnormality during mouse brain development. Morphological and biochemical analyses revealed that Wdr45 was expressed in a developmental stage-dependent manner in mouse brain.

[Nature Communications] Investigators reported the development of a complete labeling and imaging pipeline using genetic code expansion and non-canonical amino acids in neurons that allows to fluorescently label masked epitopes in target transmembrane proteins in live neurons, both in dissociated culture and organotypic brain slices.

[Nature Neuroscience] Using transplantation of wild-type (WT) neurons, the authors showed that amyloid beta (Aβ) entered WT grafts, and that this was accompanied by microglia infiltration.