neurons

[Translational Psychiatry] Scientists found that bilobalide inhibited Aβ-induced and STAT3-dependent expression of TNF-α, IL-1β, and IL-6 in primary astrocyte culture.

[American Journal of Human Genetics] Scientists established a pipeline for characterizing an allelic series of dystonia-specific mutations. They used this strategy to investigate the molecular consequences of genetic variation in THAP1, which encoded a transcription factor linked to neural differentiation.

[Science Signaling] Scientists found that GABABR phosphorylated the kinase JNK downstream of activation of the small guanosine triphosphatases RhoA and Rac1 in primary mouse neurons.

[Molecular Genetics and Metabolism Reports] Investigators demonstrated the generation of Mucopolysaccharidosis type IIIA (MPS IIIA) iPSCs, and neural progenitor cells, the latter of which display reduced proliferation and neurogenic capacity.

[Communications Biology] The identity of a glycinergic synapse was maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptured glycine back to presynaptic terminals to preserve vesicular glycine content. The authors identified the Hedgehog pathway as a robust controller of GlyT2 expression and transport activity.

[Cell Death & Disease] Scientists provided an integrative analysis of cellular metabolism during the early stages of amyloid-β accumulation in the cerebral cortex and hippocampus of the 5xFAD mouse model of Alzheimer’s disease.