neurons

[Methods] Scientists designed a workflow to reproducibly extract proteins from brain organoids, measure global turnover using mass spectrometry, and statistically investigate turnover differences between genotypes.

[iScience] Scientists determined the impact of human cytomegalovirus infection on the transcriptome of developing neurons in an organoid model system. Cell populations were isolated from organoids based on a marker for infection and transcriptomes were defined.

[Scientific Reports] Researchers examined blood–brain barrier disruption, by assessing brain-derived neurotropic factor, neuron-specific enolase levels, and gut-blood barrier disruption by trimethylamine N-oxide in chronic kidney disease patients.

[EMBO Reports] Scientists used cerebral organoids derived from patients and genome edited-iPSCs to address pathophysiological changes associated with a complex malformation of human cortical development caused by mutations in the echinoderm microtubule-associated protein-like 1 (EML1) gene.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identifed a synaptogenic/growth-promoting role for microglia in regulating pyramidal neuron axon initial segment (AIS) synapse formation by chandelier cells, a unique interneuron subtype whose axonal terminals, called cartridges, selectively targeted the AIS.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that dopamine D2 receptors in striatal medium spiny neurons played a key role in regulating diurnal liver metabolic activities.