pancreatic cancer

[Cell Death Discovery] The authors review the function and mechanism of pyroptosis in inflammatory disease development and provide a comprehensive description of the potential role of pyroptosis in inflammatory diseases.

[Cell Death Discovery] The authors review the function and mechanism of pyroptosis in inflammatory disease development and provide a comprehensive description of the potential role of pyroptosis in inflammatory diseases.

[Journal of Experimental & Clinical Cancer Research] Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC.In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.

[Frontiers in Oncology] Pancreatic cancer cells were used to verify the in vitro and in vivo effects of solasonine. Metabolomics were used to evaluate its underlying mechanisms. Solasonine promoted PANC-1 and CFPAC-1 cell apoptosis while inhibiting their proliferation, migration and invasion.

[Epigenetics] Knockdown of fat mass and obesity-related protein (FTO) increased m6A methylation of TFPI-2 mRNA in pancreatic cancer (PC) cells, which increased mRNA stability via the m6A reader YTHDF1, resulting in up-regulation of TFPI-2 expression, and inhibited PC proliferation, colony formation, sphere formation, migration and invasion in vitro.

[Trends in Pharmacological Sciences] The authors summarize the current approaches to classification of pancreatic cancer, and highlight the feasibility and potential defects of their application in precision therapy.