pancreatic cancer

[Cell Death & Disease] Scientists delineate the key factors in pancreatic ductal adenocarcinoma derived extracellular vesicles that mediate different tumour processes.

[Biomedicine & Pharmacotherapy] MK8722 is a potent and systemic pan-AMPK activator. It is an effective, direct, allosteric activator of AMPK complex in many mammals. Scientists investigated the anti-pancreatic cancer cells effects of MK8722 on two different human pancreatic cancer cell lines.

[Aging] Maslinic acid (MA) is a triterpenoid compound of natural abundance in olive plants possessing numerous biological activities. Researchers explored the anti-tumor activity of MA on human pancreatic cancer cells and the potential underlying molecular mechanism.

[Oncogene] Researchers showed that the restoration of wild type (WT) KRAS expression in human pancreatic ductal adenocarcinoma (PDAC) cell lines with LOH at KRAS significantly attenuated the malignancy of PDAC cells both in vitro and in vivo, demonstrating a tumor-suppressive role of the WT KRAS allele.

[Aging-Us] Investigators found panaxadiol significantly inhibited proliferation, and induced apoptosis in human pancreatic cancer cell lines PANC-1 and Patu8988 in a dose-dependent manner.

[Journal of Experimental & Clinical Cancer Research] FLVCR1-AS1 expression levels in 77 pancreatic cancer tissues and matched non-tumor tissues were analyzed by qRT-PCR.