pancreatic cancer

[Monash University] Adjunct Associate Professor Charles Pilgrim from the Department of Surgery was awarded nearly $3 million for a project aiming to improve the accuracy of reporting of CT scans in pancreatic cancer to optimise care for patients.

[Gastroenterology] Autochthonous murine models of pancreatic cancer (PC) and co-implanted allografts of murine PC cell lines with adipose-derived MSCs were used to assess the role of Muc5ac in stromal heterogeneity.

[Angewandte Chemie-International Edition] Scientists generated 15 g of the tricyclic intermediate in 8 steps from ( R )-limonene and 720 mg of the penultimate bioactive intermediate in a protecting-group-free manner.

[ACS Applied Materials & interfaces] The nanoemulsions exhibited deep tumor penetration that was dependent on exocytosis and enhanced nerve growth factor gene silencing in vitro and in vivo when compared with control polycation/siRNA polyplexes.

[Cancer & Metabolism] Scientists performed thorough histopathological analyses and single-cell transcriptomics for both genotypes, Ptf1aCreER;KrasLSL-G12D and sexes.

[Ecotoxicology and Environmental Safety] Researchers described a novel computational method for characterizing toxicity, associated biological perturbations and disease outcome, called the Chemo-Phenotypic Based Toxicity Measurement. The method was validated in the in vitro, in vivo and organoid models.