pancreatic cells

[Ecotoxicology and Environmental Safety] Researchers described a novel computational method for characterizing toxicity, associated biological perturbations and disease outcome, called the Chemo-Phenotypic Based Toxicity Measurement. The method was validated in the in vitro, in vivo and organoid models.

[Journal of Trace Elements in Medicine and Biology] Scientists used an in vitro MIN6 cell model of environment-relevant cadmium exposure to elucidate the crucial role of mtROS-mediated mitochondrial dysfunction and inflammatory response in suppression of pancreatic β-cell insulin secretion.

[BMC Gastroenterology] Scientists found that palmitic acid stimulation led to M1 polarization of macrophage, which secreted cathepsin S via exosomes to pancreatic acinar cells and led to activation of the caspase1-mediated classical pyrolysis pathway.

[Autoimmunity] Expression of circ_0072088, microRNA (miR)-545-3p and solute carrier family 7 member 11 (SLC7A11) was detected by real-time quantitative PCR and western blotting.

[Oncotarget] Researchers described the radiolabeling, in vitro and in vivo evaluation of a bi-terminally PEGylated A20FMDV2 conjugated with DOTA or PCTA for 64Cu radiolabeling.

[Journal of Pathology] Pancreatic ductal metaplasia (PDM) development might involve all cell lineages of the pancreas, and acinar cells with the highest plasticity are the major source of PDM.