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pancreatic cells

Implanted Pluripotent Stem-Cell-Derived Pancreatic Endoderm Cells Secrete Glucose-Responsive C-peptide in Patients with Type 1 Diabetes

[Cell Stem Cell] The authors reported an analysis on one year of data from the first cohort of 15 patients from a single trial site that received subcutaneous implantation of cell products combined with an immunosuppressive regimen.

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Carrying Hsa-miRNA-128-3p Suppress Pancreatic Ductal Cell Carcinoma by Inhibiting Galectin-3

[Clinical and Translational Oncology] Researchers investigated the effects of exosomes extracted from human umbilical cord mesenchymal stem cells carrying hsa-miRNA-128-3p on pancreatic cancer cells.

In Vivo Bioengineering of Beta Cells with Immune Checkpoint Ligand as a Treatment for Early-Onset Type 1 Diabetes Mellitus

[ACS Nano] Investigators described a strategy that utilizes pretargeting and glycochemistry to bioengineer β cells in situ to induce β-cell-specific tolerance.

Type IIB PKA Is Highly Expressed in β Cells and Controls Cell Proliferation via Regulating Cyclin D1 Expression

[FEBS Journal] Investigators found that the RIIB subunit of protein kinase A is expressed specifically by β cells of mouse and human islets.

CHK1 Protects Oncogenic KRAS-Expressing Cells from DNA Damage and Is a Target for Pancreatic Cancer Treatment

[Cell Reports] Pharmacologic inhibition of CHK1 alone caused apoptotic growth suppression of both PDAC cell lines and organoids, which correlated with loss of MYC expression.

Aldo-Ketoreductase 1c19 Ablation Does Not Affect Insulin Secretion in Murine Islets

[PLoS One] Investigators showed that Akr1c19 expression was dramatically decreased in db/db islets.

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