pancreatic cells

[Nature Communications] Researchers reported the identification of two RNA aptamers that specifically and selectively recognize mouse and human β cells.

[Scientific Reports] Cell viability assay revealed that apiin, rhoifolin, and vitexin could inhibit proliferation of PANC-1 and ASPC-1, with rhoifolin showing the maximum inhibitory effect.

[American Journal of Physiology-Endocrinology and Metabolism] Investigators critically discuss the contributions of external, intrinsic, and paracrine factors in pancreatic β-, α-, and δ-cell secretion across the full spectrum of physiological (i.e., fasting and fed) and pathophysiological (gluco- and lipotoxicity; diabetes) environments.

[Trends in Endocrinology and Metabolism] The authors highlight the importance of studying pancreatic β-cell expansion and functional maturation signaling pathways and epigenetic programs to understand the causes of different forms of diabetes and to permit the design of novel therapeutic strategies.

[Science Translational Medicine] In response to PX-478 treatment, human islet organoids chronically exposed to high glucose presented improved stimulation index of glucose-induced insulin secretion.

[Cell Death & Disease] Researchers observed that trefoil factor 3 (TFF3) expression was elevated in PDAC, and was positively correlated with a worse overall patient survival outcome.