Clenbuterol Exerts Antidiabetic Activity through Metabolic Reprogramming of Skeletal Muscle Cells

To elucidate the underlying cellular and molecular mechanisms, researchers chronically treated wild-type mice and several newly developed mutant mouse strains with clenbuterol, a selective β2-adrenergic receptor agonist.
[Nature Communications]
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Using Adipose-Derived Mesenchymal Stem Cells to Fight the Metabolic Complications of Obesity: Where Do We Stand?

Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
[Obesity Reviews]
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Progranulin Mediates Immune Evasion of Pancreatic Ductal Adenocarcinoma through Regulation of MHCI Expression

Researchers characterized the function of tumor-derived PGRN in promoting immune evasion in primary pancreatic ductal adenocarcinoma.
[Nature Communications]
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Possibility of Adiponectin Use to Improve Islet Transplantation Outcomes

In in vitro assessment, released insulin at high glucose stimulation, insulin content, and expressions of vascular endothelial growth factor and integrin β1 were improved in adiponectin-treated islets.
[Scientific Reports]
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Microengineered Multi-Organoid System from hiPSCs to Recapitulate Human Liver-Islet Axis in Normal and Type 2 Diabetes

Investigators developed a new microfluidic multi-organoid system that recapitulated the human liver-pancreatic islet axis in normal and disease states.
[Advanced Science]
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Researchers Awarded Grant to Study New Method of Islet Transplantation

Weill Cornell Medicine researchers have received a two-year $500,000 grant from JDRF to evaluate an innovative approach to islet cell transplantation, an experimental treatment for difficult-to-control type 1 diabetes.
[Weill Cornell Medicine]
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FGD3 Binds with HSF4 to Suppress p65 Expression and Inhibit Pancreatic Cancer Progression

FGD3, which is involved in regulating the actin cytoskeleton and cell shape, has been reported to inhibit cancer cell migration and predict a favorable prognosis in multiple types of cancer. Researchers conducted a systematic investigation of the cancer-related role of FGD3 in pancreatic cancer.
[Oncogene]
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Hsa_circ_0074298 Promotes Pancreatic Cancer Progression and Resistance to Gemcitabine by Sponging miR-519 to Target SMOC

Scientists investigate the expression of hsa_circ_0074298 and the molecular mechanism that promoted tumor growth and enhanced the chemoresistance of pancreatic cancer.
[Journal of Cancer]
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Exposure to Perfluorooctane Sulfonate Reduced Cell Viability and Insulin Release Capacity of β Cells

In a cell-based in vitro bioassay, scientists used mouse β-TC-6 cancer cells and found 48-hour exposure to perfluorooctane sulfonate (PFOS) decreased the cell viability at 50 μmol/L. By measuring insulin content in supernatant, 48-hour pretreatment of PFOS (100 μmol/L) decreased the insulin release capacity of β-TC-6 cells after glucose stimulation.
[Journal of Environmental Sciences]
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Components of the Phosphatidylserine Endoplasmic Reticulum to Plasma Membrane Transport Mechanism as Targets for KRAS Inhibition in Pancreatic Cancer

Researchers showed that the phosphatidylserine (PtdSer) lipid transport proteins, ORP5 and ORP8, which are essential for maintaining plasma membrane (PM) PtdSer levels and hence KRAS PM localization, were required for KRAS oncogenesis.
[Proceedings of the National Academy of Sciences of the United States of America]
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Targeted Intervention of eIF4A1 Inhibits EMT and Metastasis of Pancreatic Cancer Cells via C-MYC/miR-9 Signaling

Investigators characterized the function of eukaryotic translation initiation factors (eIFs) in epithelial-mesenchymal-transition (EMT) and metastasis in pancreatic cancer cells to investigate whether eIFs and downstream c-MYC affect EMT and metastasis by joint interference.
[Cancer Cell International]
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