Tag results:
pancreatic cells
Pancreatic Cell News
The Physiological Role of β-Cell Heterogeneity in Pancreatic Islet Function
[Nature Reviews Endocrinology] The focus of this Review is the description of how endocrine cell heterogeneity affects the regulation of hormone secretion within the islets of Langerhans.
Pancreatic Cell News
Copine 3 “CPNE3” Is a Novel Regulator for Insulin Secretion and Glucose Uptake in Pancreatic β-Cells
[Scientific Reports] Copine 3 (CPNE3) is a calcium-dependent phospholipid-binding protein that has been found to play an essential role in cancer progression and stages. RNA sequencing and microarray data revealed that CPNE3 was highly expressed in human islets compared to other CPNE genes.
Pancreatic Cell News
Human Islet T Cells Are Highly Reactive to Preproinsulin in Type 1 Diabetes
[Proceedings of the National Academy of Sciences of the United States of America] Scientists comprehensively examined preproinsulin specificity of CD8 T cells obtained from pancreatic islets of organ donors with and without type 1 diabetes (T1D) and identified epitopes throughout the entire preproinsulin protein and defective ribosomal products derived from preproinsulin messenger RNA.
Pancreatic Cell News
Marker-Free Lineage Tracing Reveals an Environment-Instructed Clonogenic Hierarchy in Pancreatic Cancer
[Cell Reports] Researchers used marker-independent stochastic clonal labeling, combined with quantitative modeling of tumor expansion, to uncover pancreatic ductal adenocarcinoma tissue growth dynamics.
Pancreatic Cell News
The Healthy Exocrine Pancreas Contains Preproinsulin-Specific CD8 T Cells That Attack Islets in Type 1 Diabetes
[Science Advances] The authors quantified preproinsulin-specific CD8+ T cells within different areas of the human pancreas from nondiabetic controls, autoantibody-positive donors, and donors with type 1 diabetes to investigate their role in diabetes development.
Pancreatic Cell News
MK8722, an AMPK Activator, Inhibiting Carcinoma Proliferation, Invasion and Migration in Human Pancreatic Cancer Cells
[Biomedicine & Pharmacotherapy] MK8722 is a potent and systemic pan-AMPK activator. It is an effective, direct, allosteric activator of AMPK complex in many mammals. Scientists investigated the anti-pancreatic cancer cells effects of MK8722 on two different human pancreatic cancer cell lines.