pancreatic cells

[Aging] Maslinic acid (MA) is a triterpenoid compound of natural abundance in olive plants possessing numerous biological activities. Researchers explored the anti-tumor activity of MA on human pancreatic cancer cells and the potential underlying molecular mechanism.

[Islets] Scientists identified genes that were specifically expressed in pancreatic islet β-cells. Large-scale complementary DNA-sequencing analysis was performed for 3,429 expressed sequence tags derived from murine MIN6 β-cells, through homology comparisons using the GenBank database.

[Oncogene] Researchers showed that the restoration of wild type (WT) KRAS expression in human pancreatic ductal adenocarcinoma (PDAC) cell lines with LOH at KRAS significantly attenuated the malignancy of PDAC cells both in vitro and in vivo, demonstrating a tumor-suppressive role of the WT KRAS allele.

[Molecular Cancer] Investigators shed light on recent advances regarding the direct and indirect crosstalk between cancer-associated fibroblasts (CAFs) and infiltrating immune cells and further summarize the possible immunoinhibitory mechanisms induced by CAFs in the tumor microenvironment.

[Cell Reports] Scientists created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating over 500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems.

[Aging-Us] Investigators found panaxadiol significantly inhibited proliferation, and induced apoptosis in human pancreatic cancer cell lines PANC-1 and Patu8988 in a dose-dependent manner.