pancreatic cells

[Molecular Cancer Research] Researchers functionally studied candidate proteins using human normal and cancerous pancreatic ductal epithelial cell lines. 10-22 cell-derived pancreatic ductal adenocarcinoma (PDAC) displayed the molecular signature of clinical human PDAC.

[Cell Reports] Type 1 diabetes (T1D) patients had a lower serum MOTS-c level than did healthy controls. Furthermore, MOTS-c reduced T cell activation by alleviating T cells from the glycolytic stress in T1D patients, suggesting therapeutic potential.

[Journal of Biological Chemistry] Researchers investigated the effects of different doses of metformin on AQP7 expression and explored the possible mechanism of its protective effects in the pancreatic islets.

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Scientists demonstrated that tripartite motif (TRIM) expression was elevated in pancreatic ductal adenocarcinomas tissues, and this elevated expression was associated with a poor prognosis.

[Cancer Letters] Scientists investigated the role of ANGPTL4 in KRASG12D-induced acinar-to-ductal metaplasia, pancreatic intraepithelial neoplasia formation, and pancreatic ductal adenocarcinoma maintenance.

[Gastroenterology] Pancreas-specific Agr2 ablation was performed to access its role in pancreatic carcinogenesis. Hydrophobic hexapeptides loaded in liposomes were developed to disrupt Agr2-RNAPII complex.