pancreatic ductal adenocarcinoma

[Cancer Letters] Scientists investigated the role of ANGPTL4 in KRASG12D-induced acinar-to-ductal metaplasia, pancreatic intraepithelial neoplasia formation, and pancreatic ductal adenocarcinoma maintenance.

[Gastroenterology] Pancreas-specific Agr2 ablation was performed to access its role in pancreatic carcinogenesis. Hydrophobic hexapeptides loaded in liposomes were developed to disrupt Agr2-RNAPII complex.

[Scientific Reports] Researchers described the distribution of GNA15 in adenocarcinoma from human pancreatic specimens and analyzed the mechanism driving abnormal expression and the consequences on signaling and clinical follow-up.

[Journal of Gastroenterology] Researchers discussed the intracellular signal events contributing to pancreatic myofibroblasts activation, and crosstalk with different components of tumor microenvironment.

[Journal of Proteome Research] The impact of DNAJA1 expression on pancreatic ductal adenocarcinoma progression remains unclear. The metabolic impacts of increased DNAJA1 expression were evaluated using a combination of untargeted metabolomics, stable isotope-resolved metabolomics, confocal microscopy, flow cytometry, and cell-based assays.

[Cell Death & Disease] Researchers found that dihydroartemisinin (DHA) could intensively strengthen the cytotoxicity of cisplatin and significantly reduced its effective concentrations both in vitro and in vivo.