prostate cancer cells

[Natural Product Research] Among the compounds tested, compounds 9i and 9k potently arrested proliferation of DU-145, the prostate cancer cell line.

[Oncology Reports] Researchers analyzed the effect of curcumol on prostate cancer and identify its possible internal regulatory pathway using in vitro cell culture and in vivo tumor model experiments.

[PLOS One] Researchers observed that bergamottin reduced prostate cancer cell growth by decreasing both total and nuclear AR reducing downstream AR signaling.

[Scientific Reports] The authors designed and synthesized a new prostate-specific membrane antigen-targeted radiotracer, 68Ga-SC691, with high affinity for prostate cancer cells and excellent pharmacokinetics.

[ACS Chemical Biology] Investigators described the identification of 2-(4-fluorophenyl)-5-(trifluoromethyl)-1,3-benzothiazole, a small molecule that inhibits BAG1L– androgen receptor (AR) N-terminal domain (NTD) interaction, attenuated BAG1L-mediated AR NTD activity, downregulated AR target gene expression, and inhibited proliferation of AR-positive prostate cancer cells.

[Future Medicinal Chemistry] To outline the inhibitory role of HIC on prostate cancer cells, PC-3 and DU145 cell lines were treated with the respective IC50 concentrations, which reduced cell proliferation, adherence properties and spheroid formation.