prostate cancer

[Radiotherapy and Oncology] The authors investigated the effect of a novel oxygen-generating polymer-lipid manganese dioxide nanoparticle on improving radiation therapy (RT) outcomes in CRPC xenograft models by modulating the tumor microenvironment both before and after RT.

[Prostate] Depletion of βarrestin1 in androgen receptor-null CRPC cells inhibited glucocorticoid receptor function and CRPC growth and invasion in both in vitro and in vivo settings.

[Cancer Letters] In vivo and in vitro experiments were performed to evaluate the functions of circ_0086722 in prostate cancer.

[International Immunopharmacology] Scientists showed that downregulation of METTL3 in prostate cancer tumor-associated macrophages modulated macrophages toward an M2-like phenotype and that this modulation was mediated by activation of STAT6.

[Drug Development Research] Transient receptor potential cation channel subfamily M member 2 antisense RNA (TRPM2-AS) knockdown suppressed cell progression and paclitaxel (PTX) resistance in PTX-resistant prostate cancer cells by miR-497-5p/FOXK1 axis.

[Cancer Cell International] In vitro experiments revealed that targeting LMNB1 had a synergistic effect on prostate cancer with PARP inhibitor treatment.