Redox-Responsive Nanoparticles Enhance Radiation Therapy by Altering Multifaceted Radio-Resistance Mechanisms in Human Castration-Resistant Prostate Cancer Cells and Xenografts

The authors investigated the effect of a novel oxygen-generating polymer-lipid manganese dioxide nanoparticle on improving radiation therapy (RT) outcomes in CRPC xenograft models by modulating the tumor microenvironment both before and after RT.