Investigators found that lentiviral-mediated knockdown of ATG9A in intestinal epithelial cells prevented epithelial barrier formation by >95% and resulted in significant mislocalization of multiple tight junction proteins.
Investigators analyzed bone marrow and found that gemfibrozil reduced erythrocytes and hematopoietic stem cells in wild-type mice but not in PPAR-alpha-knockout mice, while increased colony-forming units were observed only in wild-type mice treated with gemfibrozil.
