Specific variations in YTHDF1 expression were detected in YTHDF1-overexpressing, -knockout, and -knockdown human hepatocellular carcinoma (HCC) cells, HCC organoids, and HCC patient-derived xenograft murine models.
[Signal Transduction and Targeted Therapy]
Li, Q., Ni, Y., Zhang, L., Jiang, R., Xu, J., Yang, H., Hu, Y., Qiu, J., Pu, L., Tang, J., & Wang, X. (2021). HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-020-00453-8 Cite
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