Tag Archives: HIF

Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing through MiR-17-5p-mediated Enhancement of Angiogenesis

Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
Wei, Q., Wang, Y., Ma, K., Li, Q., Li, B., Hu, W., Fu, X., & Zhang, C. (2021). Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10176-0 Cite
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Hypoxia-Inducible Factor-Dependent ADAM12 Expression Mediates Breast Cancer Invasion and Metastasis

The authors report that exposure of human breast cancer cells to hypoxia activates epidermal growth factor receptor (EGFR) signaling that was mediated by the hypoxia-inducible factor-dependent expression of a disintegrin and metalloprotease 12 (ADAM12).
[Proceedings of the National Academy of Sciences of the United States of America]
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Nano-Realgar Suppresses Lung Cancer Stem Cell Growth by Repressing Metabolic Reprogramming

Isolation and characterization of lung cancer stem cells was performed by magnetic cell sorting and immunocytochemistry, respectively.
[Gene]
Yang, F., Zhao, Y., Hu, X., Liu, Z., Yu, X., Li, C., Li, X., & Li, H. (2021). Nano-realgar suppresses lung cancer stem cell growth by repressing metabolic reprogramming. Gene, 788, 145666. https://doi.org/10.1016/j.gene.2021.145666 Cite
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MicroRNAs and Angiogenesis: A New Era for the Management of Colorectal Cancer

Scientists describe the latest advances in the understanding of miRNAs and their corresponding targets that play a role in colorectal cancer angiogenesis and discuss possible miRNA-based therapeutic strategies.
[Cancer Cell International]
Tang, Y., Zong, S., Zeng, H., Ruan, X., Yao, L., Han, S., & Hou, F. (2021). MicroRNAs and angiogenesis: a new era for the management of colorectal cancer. Cancer Cell International, 21(1), 221. https://doi.org/10.1186/s12935-021-01920-0 Cite
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Selenomethionine Protects Hematopoietic Stem/Progenitor Cells against Cobalt Nanoparticles by Stimulating Antioxidant Actions and DNA Repair Functions

The authors investigated the mechanism underlying the toxic effect of cobalt nanoparticles (CoNPs) on HSCs/hematopoietic progenitor cells and to determine the protective effect of selenomethionine against CoNPs in vitro and in vivo.
[Aging]
Zhu, W., Liu, Y., Zhang, W., Fan, W., Wang, S., Gu, J.-H., Sun, H., & Liu, F. (2021). Selenomethionine protects hematopoietic stem/progenitor cells against cobalt nanoparticles by stimulating antioxidant actions and DNA repair functions. Aging, 13. https://doi.org/10.18632/aging.202865 Cite
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HIF-1α Promoted Vasculogenic Mimicry Formation in Lung Adenocarcinoma through NRP1 Upregulation in the Hypoxic Tumor Microenvironment

Researchers explored the role of the HIF-1α/NRP1 axis in mediating lung adenocarcinoma metastasis and vasculogenic mimicry (VM) formation.
[Cell Death & Disease]
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Mutant KRAS Triggers Functional Reprogramming of Tumor-Associated Macrophages in Colorectal Cancer

Mutationally activated KRAS in tumor cells reprograms macrophages to a tumor-associated macrophage-like phenotype via a combination effect of tumor-derived CSF2 and lactate.
[Signal Transduction and Targeted Therapy]
Liu, H., Liang, Z., Zhou, C., Zeng, Z., Wang, F., Hu, T., He, X., Wu, X., Wu, X., & Lan, P. (2021). Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-021-00534-2 Cite
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NDUFA4L2 Promotes Glioblastoma Progression, Is Associated with Poor Survival, and Can Be Effectively Targeted by Apatinib

Gene knockdown of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) inhibited tumor cell proliferation and enhanced apoptosis, while tumor cells initiated protective mitophagy in vitro and in vivo.
[Cell Death & Disease]
Chen, Z., Wei, X., Wang, X., Zheng, X., Chang, B., Shen, L., Zhu, H., Yang, M., Li, S., & Zheng, X. (2021). NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03646-3 Cite
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Dual Effects of Hypoxia on Proliferation and Osteogenic Differentiation of Mouse Clonal Mesenchymal Stem Cells

Mouse clonal MSCs were cultured on a Cytodex 3 microcarrier in a spinner flask for a suspension culture under hypoxia condition to increase mass productivity.
[Bioprocess and Biosystems Engineering]
Kim, H., & Kwon, S. (2021). Dual effects of hypoxia on proliferation and osteogenic differentiation of mouse clonal mesenchymal stem cells. Bioprocess and Biosystems Engineering. https://doi.org/10.1007/s00449-021-02563-1 Cite
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Hypoxia-Inducible Factor-2α Mediates Senescence-Associated Intrinsic Mechanisms of Age-Related Bone Loss

Inhibition of senescence-induced upregulation of hypoxia-inducible factor-2α expression during matrix maturation, but not during the proliferation stage of osteoblast differentiation, reversed the age-related decrease in Runx2 and Ocn expression.
[Experimental and Molecular Medicine]
Lee, S. Y., Park, K. H., Lee, G., Kim, S.-J., Song, W.-H., Kwon, S.-H., Koh, J.-T., Huh, Y. H., & Ryu, J.-H. (2021). Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Experimental & Molecular Medicine, 1–14. https://doi.org/10.1038/s12276-021-00594-y Cite
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Hypoxic and Pharmacological Activation of HIFs Inhibits SARS-CoV-2 Infection of Lung Epithelial Cells

Scientists demonstrated that hypoxia and the hypoxia inducible factor (HIF) prolyl hydroxylase inhibitor Roxadustat reduced angiotensin-converting enzyme expression and inhibited SARS-CoV-2 entry and replication in lung epithelial cells via a HIF-1α dependent pathway.
[Cell Reports]
Wing, P. A., Keeley, T. P., Zhuang, X., Lee, J. Y., Prange-Barczynska, M., Tsukuda, S., Morgan, S. B., Harding, A. C., Argles, I. L. A., Kurlekar, S., Noerenberg, M., Thompson, C. P., Huang, K.-Y. A., Balfe, P., Watashi, K., Castello, A., Hinks, T. S., James, W., Ratcliffe, P. J., … McKeating, J. A. (2021). Hypoxic and pharmacological activation of HIFs inhibits SARS-CoV-2 infection of lung epithelial cells. Cell Reports, 0(0). https://doi.org/10.1016/j.celrep.2021.109020 Cite
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