The HIF Target ATG9A is Essential for Epithelial Barrier Function and Tight Junction Biogenesis

Investigators found that lentiviral-mediated knockdown of ATG9A in intestinal epithelial cells prevented epithelial barrier formation by >95% and resulted in significant mislocalization of multiple tight junction proteins.
[Molecular Biology of the Cell]
Abstract

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Gemfibrozil Induces Anemia, Leukopenia and Reduces Hematopoietic Stem Cells via PPAR-α in Mice

Investigators analyzed bone marrow and found that gemfibrozil reduced erythrocytes and hematopoietic stem cells in wild-type mice but not in PPAR-alpha-knockout mice, while increased colony-forming units were observed only in wild-type mice treated with gemfibrozil.
[International Journal of Molecular Sciences]
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