Tag Archives: HIF

Sorafenib Attenuates Liver Fibrosis by Triggering Hepatic Stellate Cell Ferroptosis via HIF-1α/SLC7A11 Pathway

Scientists investigate the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and extracellular matrix accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.
[Cell Proliferation]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Sevoflurane Preconditioning Promotes Mesenchymal Stem Cells to Relieve Myocardial Ischemia/Reperfusion Injury via TRPC6-Induced Angiogenesis

The authors investigated whether sevoflurane preconditioning could promote MSCs to attenuate myocardial I/R injury via transient receptor potential canonical channel 6 (TRPC6)-induced angiogenesis.
[Stem Cell Research & Therapy]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Extracellular Vesicles Derived from Hypoxia-Preconditioned Olfactory Mucosa Mesenchymal Stem Cells Enhance Angiogenesis via miR-612

Investigators explored the effects of extracellular vesicles from human hypoxic olfactory mucosa MSCs on angiogenesis and its underlying mechanism.
[Journal of Nanobiotechnology]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Melittin and Diclofenac Synergistically Promote Wound Healing in a Pathway Involving TGF-β1

Melittin (MEL)-diclofenac (DCL) nano-complexes exhibited better regenerated epithelium, keratinization, epidermal proliferation, and granulation tissue formation and better wound healing activity than controls. Treatment of wounded skin with MEL-DCL nano-complexes showed an increase in mRNA expression levels of collagen.
[Pharmacological Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Hif-1a Suppresses ROS-Induced Proliferation of Cardiac Fibroblasts Following Myocardial Infarction

Investigators reported that cardiac fibroblasts and mesenchymal progenitors are more hypoxic than other cardiac interstitial populations, express more hypoxia-inducible factor 1α (HIF-1α), and exhibited increased glycolytic metabolism.
[Cell Stem Cell]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractPress ReleaseGraphical Abstract
Bookmark

No account yet? Register

Share

Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis

Scientists defined for the first time an unexpected role of endothelial PHD2 deficiency in inducing cardiac hypertrophy and fibrosis in an HIF‐2α–dependent manner.
[Journal of the American Heart Association]
[zotpress userid=” items=’DDDDDDDD’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Revisiting the HIF Switch in the Tumor and Its Immune Microenvironment

Investigators summarize current knowledge on the unique contributions of the two HIF-α isoforms to tumor progression in the context of the complex tumor immune microenvironment, highlighting important considerations for therapy.
[Trends in Cancer]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

HIF-1–Regulated Expression of Calreticulin Promotes Breast Tumorigenesis and Progression through Wnt/β-Catenin Pathway Activation

Researchers demonstrated that calreticulin facilitated breast cancer progression by promoting the breast cancer stem cell phenotype through Wnt/β-catenin signaling in a hypoxia-inducible factor 1 (HIF-1)–dependent manner.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Hypoxia Induces Stress Fiber Formation in Adipocytes in the Early Stage of Obesity

Scientists developed an in vitro model of adipose tissue to study adipocyte-fibroblast crosstalk in a hypoxic environment. The model was used to investigate the effect of hypoxia on adipocyte mechanical properties via ras homolog gene family member A (RhoA)/Rho-associated coiled-coil kinases signaling pathways.
[Scientific Reports]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

HIF-1α Promotes the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via Activation of Cx43

The authors suggested that HIF-1α, as an upstream regulator, promoted the expression of Connexin 43 (Cx43), and the HIF-1α/Cx43 axis regulated the proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.
[Journal of Cellular and Molecular Medicine]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Cardiac Aorta-Derived Extracellular Matrix Scaffold Enhances Critical Mediators of Angiogenesis in Isoproterenol-Induced Myocardial Infarction Mice

The authors investigated whether cardiomyocytes culturing on cardiac aorta-derived extracellular matrix scaffold had advantageous effects on cardiomyocytes survival and angiogenesis biomarkers’ expression.
[Journal of Materials Science-Materials in Medicine]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share
Share