Chemical Hypoxia Induces Apoptosis of Human Pluripotent Stem Cells by a NOXA-Mediated HIF-1α and HIF-2α Independent Mechanism

In order to evaluate the effect of chemically mimicked hypoxia on human PSCs cell survival, scientists analyzed changes in cell viability and several aspects of apoptosis triggered by CoCl2 and dimethyloxalylglycine.
[Scientific Reports]
Isaja, L., Mucci, S., Vera, J., Rodríguez-Varela, M. S., Marazita, M., Morris-Hanon, O., Videla-Richardson, G. A., Sevlever, G. E., Scassa, M. E., & Romorini, L. (2020). Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism. Scientific Reports, 10(1), 20653. https://doi.org/10.1038/s41598-020-77792-7 Cite
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The Importance of Hypoxia-Inducible Factors (HIF-1 and HIF-2) for the Pathophysiology of Inflammatory Bowel Disease

Myeloid hypoxia inducible factors(HIF)-1α and HIF-2α played opposing roles in acute dextran sodium sulfate colitis. Thus, not only a cell type specific, but also the isoform specific modulation of HIFs needs to be addressed in attempts to modify HIF for therapeutic purposes.
[International Journal of Molecular Sciences]
Kerber, E. L., Padberg, C., Koll, N., Schuetzhold, V., Fandrey, J., & Winning, S. (2020). The Importance of Hypoxia-Inducible Factors (HIF-1 and HIF-2) for the Pathophysiology of Inflammatory Bowel Disease. International Journal of Molecular Sciences, 21(22), 8551. https://doi.org/10.3390/ijms21228551 Cite
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Hypoxic Glioma Stem Cell-Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/C-Myc/HIF-1α

Scientists explored the mechanisms by which lncRNA derived from hypoxic glioma stem cells cause glioma progression. Isolation and identification of the Linc01060 gene, the exosomes containing them, and the proteins from tumor cells regulating the gene allowed for studying the effects of Linc01060 on proliferation and glycometabolism.
[Cancer Research]
Li, J., Liao, T., Liu, H., Yuan, H., Ouyang, T., Wang, J., Chai, S., Li, J., Chen, J., Li, X., Zhao, H., & Xiong, N. (2020). Hypoxic glioma stem cell-derived exosomes containing Linc01060 promote progression of glioma by regulating the MZF1/c-Myc/HIF-1α. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2270 Cite
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Hypoxia-Inducible factor-2α is Crucial for Proper Brain Development

In search of the underlying mechanisms for the specific loss of pyramidal cells in the retrosplenial cortex, the authors found deficits in migration in neural stem cells from Hif-2α knockout mice due to altered expression patterns of genes highly associated with neuronal migration and positioning.
[Scientific Reports]
Kleszka, K., Leu, T., Quinting, T., Jastrow, H., Pechlivanis, S., Fandrey, J., & Schreiber, T. (2020). Hypoxia-inducible factor-2α is crucial for proper brain development. Scientific Reports, 10(1), 19146. https://doi.org/10.1038/s41598-020-75838-4 Cite
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An Allosteric Peptide Inhibitor of HIF-1α Regulates Hypoxia-Induced Retinal Neovascularization

Researchers showed that a peptide fragment of CITED2 was taken up by retinal cells and efficiently regulated pathological angiogenesis in murine models of ischemic retinopathy.
[Proceedings of the National Academy of Sciences of the United States of America]
Usui-Ouchi, A., Aguilar, E., Murinello, S., Prins, M., Gantner, M. L., Wright, P. E., Berlow, R. B., & Friedlander, M. (2020). An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2017234117 Cite
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Genetically Engineered Magnetic Nanocages for Cancer Magneto-Catalytic Theranostics

Scientists demonstrated that encapsulin-produced magnetic iron oxide nanocomposites had excellent magnetic saturation and remnant magnetization properties, featuring superior magnetic-to-thermal conversion efficiency with an ultrahigh specific absorption rate of 2390 W/g to overcome the critical issues of magnetic hyperthermia therapy.
[Nature Communications]
Zhang, Y., Wang, X., Chu, C., Zhou, Z., Chen, B., Pang, X., Lin, G., Lin, H., Guo, Y., Ren, E., Lv, P., Shi, Y., Zheng, Q., Yan, X., Chen, X., & Liu, G. (2020). Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics. Nature Communications, 11(1), 5421. https://doi.org/10.1038/s41467-020-19061-9 Cite
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Neddylation Blockade Induces HIF-1α Driven Cancer Cell Migration via Upregulation of ZEB1

Scientists report that inhibiting neddylation activates the hypoxia-inducible factor 1α (HIF-1α) through the PI3K-Akt pathway, which eventually regulates the epithelial to mesenchymal transition-activator zinc finger E-box binding homeobox 1 (ZEB1) in various cancer cell lines.
[Scientific Reports]
Park, J. B., Seo, J., Park, J.-W., & Chun, Y.-S. (2020). Neddylation blockade induces HIF-1α driven cancer cell migration via upregulation of ZEB1. Scientific Reports, 10(1), 18210. https://doi.org/10.1038/s41598-020-75286-0 Cite
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Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function

Using a model of chronic hypoxia-inducible factor 1a (HIF1a) accumulation in pluripotent stem cell-derived oligodendrocyte progenitors (OPCs), scientists demonstrated that HIF1a activates non-canonical targets to impair generation of oligodendrocytes from OPCs.
[Cell Stem Cell]
Allan, K. C., Hu, L. R., Scavuzzo, M. A., Morton, A. R., Gevorgyan, A. S., Cohn, E. F., Clayton, B. L. L., Bederman, I. R., Hung, S., Bartels, C. F., Madhavan, M., & Tesar, P. J. (2020). Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.09.019 Cite
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Breast Cancer–Associated Macrophages Promote Tumorigenesis by Suppressing Succinate Dehydrogenase in Tumor Cells

Researchers isolated macrophages from mice and humans, polarized them ex vivo, and examined their functional interaction with breast cancer cells in culture and in mice.
[Science Signaling]
Gómez, V., Eykyn, T. R., Mustapha, R., Flores-Borja, F., Male, V., Barber, P. R., Patsialou, A., Green, R., Panagaki, F., Li, C. W., Fruhwirth, G. O., Ros, S., Brindle, K. M., & Ng, T. (2020). Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells. Science Signaling, 13(652). https://doi.org/10.1126/scisignal.aax4585 Cite
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HIF-2α Is Indispensable for Regulatory T Cell Function

Researchers showed that Treg cell development was normal in mice with Foxp3-specific knockout of hypoxia-inducible factor 1α (HIF-1α) or HIF-2α.
[Nature Communications]
Hsu, T.-S., Lin, Y.-L., Wang, Y.-A., Mo, S.-T., Chi, P.-Y., Lai, A. C.-Y., Pan, H.-Y., Chang, Y.-J., & Lai, M.-Z. (2020). HIF-2α is indispensable for regulatory T cell function. Nature Communications, 11(1), 5005. https://doi.org/10.1038/s41467-020-18731-y Cite
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Targeting HIF2α-ARNT Hetero-Dimerisation as a Novel Therapeutic Strategy for Pulmonary Arterial Hypertension

Blood outgrowth endothelial cells from idiopathic pulmonary artery hypertension patients were used to determine the impact of HIF2α-inhibition on endothelial function.
[European Respiratory Journal]
Macias, D., Moore, S., Crosby, A., Southwood, M., Du, X., Tan, H., Xie, S., Vassallo, A., Wood, A. J., Wallace, E. M., & Cowburn, A. S. (2020). Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for Pulmonary Arterial Hypertension. European Respiratory Journal. https://doi.org/10.1183/13993003.02061-2019 Cite
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