Sorafenib Attenuates Liver Fibrosis by Triggering Hepatic Stellate Cell Ferroptosis via HIF-1α/SLC7A11 Pathway

Scientists investigate the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and extracellular matrix accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.
[Cell Proliferation]
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Sevoflurane Preconditioning Promotes Mesenchymal Stem Cells to Relieve Myocardial Ischemia/Reperfusion Injury via TRPC6-Induced Angiogenesis

The authors investigated whether sevoflurane preconditioning could promote MSCs to attenuate myocardial I/R injury via transient receptor potential canonical channel 6 (TRPC6)-induced angiogenesis.
[Stem Cell Research & Therapy]
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Extracellular Vesicles Derived from Hypoxia-Preconditioned Olfactory Mucosa Mesenchymal Stem Cells Enhance Angiogenesis via miR-612

Investigators explored the effects of extracellular vesicles from human hypoxic olfactory mucosa MSCs on angiogenesis and its underlying mechanism.
[Journal of Nanobiotechnology]
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Melittin and Diclofenac Synergistically Promote Wound Healing in a Pathway Involving TGF-β1

Melittin (MEL)-diclofenac (DCL) nano-complexes exhibited better regenerated epithelium, keratinization, epidermal proliferation, and granulation tissue formation and better wound healing activity than controls. Treatment of wounded skin with MEL-DCL nano-complexes showed an increase in mRNA expression levels of collagen.
[Pharmacological Research]
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Hif-1a Suppresses ROS-Induced Proliferation of Cardiac Fibroblasts Following Myocardial Infarction

Investigators reported that cardiac fibroblasts and mesenchymal progenitors are more hypoxic than other cardiac interstitial populations, express more hypoxia-inducible factor 1α (HIF-1α), and exhibited increased glycolytic metabolism.
[Cell Stem Cell]
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Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis

Scientists defined for the first time an unexpected role of endothelial PHD2 deficiency in inducing cardiac hypertrophy and fibrosis in an HIF‐2α–dependent manner.
[Journal of the American Heart Association]
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Revisiting the HIF Switch in the Tumor and Its Immune Microenvironment

Investigators summarize current knowledge on the unique contributions of the two HIF-α isoforms to tumor progression in the context of the complex tumor immune microenvironment, highlighting important considerations for therapy.
[Trends in Cancer]
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HIF-1–Regulated Expression of Calreticulin Promotes Breast Tumorigenesis and Progression through Wnt/β-Catenin Pathway Activation

Researchers demonstrated that calreticulin facilitated breast cancer progression by promoting the breast cancer stem cell phenotype through Wnt/β-catenin signaling in a hypoxia-inducible factor 1 (HIF-1)–dependent manner.
[Proceedings of the National Academy of Sciences of the United States of America]
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Hypoxia Induces Stress Fiber Formation in Adipocytes in the Early Stage of Obesity

Scientists developed an in vitro model of adipose tissue to study adipocyte-fibroblast crosstalk in a hypoxic environment. The model was used to investigate the effect of hypoxia on adipocyte mechanical properties via ras homolog gene family member A (RhoA)/Rho-associated coiled-coil kinases signaling pathways.
[Scientific Reports]
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HIF-1α Promotes the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via Activation of Cx43

The authors suggested that HIF-1α, as an upstream regulator, promoted the expression of Connexin 43 (Cx43), and the HIF-1α/Cx43 axis regulated the proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.
[Journal of Cellular and Molecular Medicine]
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Cardiac Aorta-Derived Extracellular Matrix Scaffold Enhances Critical Mediators of Angiogenesis in Isoproterenol-Induced Myocardial Infarction Mice

The authors investigated whether cardiomyocytes culturing on cardiac aorta-derived extracellular matrix scaffold had advantageous effects on cardiomyocytes survival and angiogenesis biomarkers’ expression.
[Journal of Materials Science-Materials in Medicine]
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