Tag Archives: xenograft models

Supraphysiological Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer

Investigators reported that supraphysiological levels of testosterone (SupraT) activated cytoplasmic nucleic acid sensors and induced growth inhibition of SupraT-sensitive prostate cancer cells.
[Cancer Research]
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Targeting KDM6A Suppresses SREBP1c-Dependent Lipid Metabolism and Prostate Tumorigenesis

Scientists reported that specific homozygous deletion of KDM6A in the adult mouse prostate epithelium strongly inhibited tumor progression initiated by the homozygous loss of PTEN. Mechanistically, KDM6A promoted prostate tumorigenesis and lipid metabolism by binding to the SREBP1c promoter which resulted in increased SREBP1c transcription.
[Cancer Research]
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FBXW11 Contributes to Stem-Cell-Like Features and Liver Metastasis through Regulating HIC1-Mediated SIRT1 Transcription in Colorectal Cancer

The authors explored the role of F-box and WD repeat domain containing 11 (FBXW11) in the development and metastasis of colorectal cancer (CRC). FBXW11 was overexpressed in colorectal tumor tissues and its overexpression was associated with a poor prognosis of CRC patients.
[Cell Death & Disease]
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Oncogenic Role of SOX9-DHCR24-Cholesterol Biosynthesis Axis in IGH-BCL2 Positive Diffuse Large B-Cell Lymphomas

Silencing of SOX9 decreased cell proliferation, induced G1/S arrest and increased apoptosis of diffuse large B-cell lymphoma cells, both in vitro and in vivo.
[Blood]
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RING-Finger Protein 6 Promotes Colorectal Tumorigenesis by Transcriptionally Activating SF3B2

To understand whether transcriptional activity of RING-finger protein 6 (RNF6) underlied its oncogenic effect, the authors performed integrated chromatin immunoprecipitation-sequencing and RNA-sequencing analysis to identify splicing factor 3b subunit 2 (SF3B2) as a potential downstream target of RNF6.
[Oncogene]
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FOXC1 Modulates Stem-Like Cell Properties and Chemoresistance through Hedgehog and EMT Signaling in Gastric Adenocarcinoma

The function of the only gene overexpressed in both chemoresistant tumors and tumor tissue relative to normal gastric epithelia, FOXC1, was examined in gastric adenocarcinoma cells, mouse xenograft models, and patient-derived organoid systems, focusing on cancer stem-like cell phenotypes, metastasis, and chemoresistance
[Molecular Therapy]
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Synergistic Targeting of BRCA1 Mutated Breast Cancers with PARP and CDK2 Inhibition

In cell lines, BRCA1 loss was associated with stabilized cyclin E1 during the cell cycle, and BRCA1 siRNA led to increased cyclin E1 in association with reduced phospho-cyclin E1 T62.
[npj Breast Cancer]
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TMED3 Promotes the Progression and Development of Lung Squamous Cell Carcinoma by Regulating EZR

The loss-of-function assays were used to investigate the effects of trafficking protein 3 on proliferation, apoptosis, cell cycle, and migration of lung squamous cell carcinoma cells.
[Cell Death & Disease]
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A Review on the Role of PCAT6 lncRNA in Tumorigenesis

Scientists summarize the impact of PCAT6 in the development of diverse types of cancers, based on the results of functional studies in cell lines, experiments in xenograft models of cancers and expression studies in samples obtained from human subjects.
[Biomedicine & Pharmacotherapy]
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Consistent Tumorigenesis with Self-Assembled Hydrogels Enables High-Powered Murine Cancer Studies

Researchers demonstrated a method for tumor inoculation using self-assembled hydrogels to reliably generate tumors with low variance in growth.
[Communications Biology]
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