xenograft models

[Cancer Research] Investigators showed that the mitochondrial calcium uniporter promoted pancreatic ductal adenocarcinoma cell migration, invasion, metastasis, and metabolic stress resistance by activating the Keap1-Nrf2 antioxidant program.

[Cell Death & Disease] Inhibition of mitochondrial apoptosis or of Caspase-activated DNAse reduced the number of micronuclei in tumor cell lines as well as the number of chromosomal misalignments in tumor cells and intestinal organoids.

[Frontiers in Oncology] Pancreatic cancer cells were used to verify the in vitro and in vivo effects of solasonine. Metabolomics were used to evaluate its underlying mechanisms. Solasonine promoted PANC-1 and CFPAC-1 cell apoptosis while inhibiting their proliferation, migration and invasion.

[Cell Death & Disease] Investigators showed that when Hsp70-binding protein 1 (HspBP1) was either knocked down or overexpressed in BRCA1-proficient breast cancer cells, there were profound changes in tumorigenesis, including anchorage-independent cell growth in vitro and in tumor formation in xenograft models.

[Military Medical Research] Investigators developed a stepwise reprogramming strategy to convert fibroblasts into sweat gland lineages, which may provide a promising method to obtain desirable cell types for the functional repair and regeneration of damaged skin.

[Biomarker Research] Inactivation of BCL11B were performed by CRISPR/Cas9 in human T cells. Immunophenotypic and transcriptional profiles of sgBCL11B T cells were characterized by cytometer and transcriptomics, respectively.