Tag Archives: xenograft models

Generation of Reconstituted Hemato-Lymphoid Murine Embryos by Placental Transplantation into Embryos Lacking HSCs

Scientists established a procedure for placental HSC transplantation into E11.5 Runx1-deficient mice mated with G1-HRD-Runx1 transgenic mice that had no HSCs in the fetal liver.
[Scientific Reports]
Jeon, H., Asano, K., Wakimoto, A., Kulathunga, K., Tran, M. T. N., Nakamura, M., Yokomizo, T., Hamada, M., & Takahashi, S. (2021). Generation of reconstituted hemato-lymphoid murine embryos by placental transplantation into embryos lacking HSCs. Scientific Reports, 11(1), 4374. https://doi.org/10.1038/s41598-021-83652-9 Cite
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EDC3 Phosphorylation Regulates Growth and Invasion through Controlling P-Body Formation and Dynamics

Prostate cancer cells harboring an mRNA decapping 3 (EDC3) serine 161A mutation showed markedly decreased growth, migration, and invasion in tissue culture and in xenograft models.
[EMBO Reports]
Bearss, J. J., Padi, S. K., Singh, N., Cardo‐Vila, M., Song, J. H., Mouneimne, G., Fernandes, N., Li, Y., Harter, M. R., Gard, J. M., Cress, A. E., Peti, W., Nelson, A. D., Buchan, J. R., Kraft, A. S., & Okumura, K. (2021). EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics. EMBO Reports, e50835. https://doi.org/10.15252/embr.202050835 Cite
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M2 Macrophage-Derived Exosomal MicroRNA-155-5p Promotes the Immune Escape of Colon Cancer by Downregulating ZC3H12B

The authors explored the possible role of M2 macrophage-derived exosomal miR-155-5p in regard to immune escape of colon cancer cells.
[Molecular Therapy-Oncolytics]
Ma, Y.-S., Wu, T.-M., Ling, C.-C., Yu, F., Zhang, J., Cao, P.-S., Gu, L.-P., Wang, H.-M., Xu, H., Li, L., Wu, Z.-J., Wang, G.-R., Li, W., Lin, Q.-L., Liu, J.-B., & Fu, D. (2021). M2 macrophage-derived exosomal microRNA-155-5p promotes the immune escape of colon cancer by downregulating ZC3H12B. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.02.005 Cite
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The Mitotic Checkpoint Is a Targetable Vulnerability of Carboplatin-Resistant Triple Negative Breast Cancers

Investigators generated carboplatin-resistant TNBC MDA-MB-468 cell line and patient derived TNBC xenograft models.
[Scientific Reports]
Moens, S., Zhao, P., Baietti, M. F., Marinelli, O., Van Haver, D., Impens, F., Floris, G., Marangoni, E., Neven, P., Annibali, D., Sablina, A. A., & Amant, F. (2021). The mitotic checkpoint is a targetable vulnerability of carboplatin-resistant triple negative breast cancers. Scientific Reports, 11(1), 3176. https://doi.org/10.1038/s41598-021-82780-6 Cite
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Preclinical Evaluation of B7-H3-Specific Chimeric Antigen Receptor T Cells for the Treatment of Acute Myeloid Leukemia

Researchers evaluated B7-H3 as a potential target for acute myeloid leukemia-directed CAR T cell therapy.
[Clinical Cancer Research]
Lichtman, E. I., Du, H., Shou, P., Song, F., Suzuki, K., Ahn, S., Li, G., Ferrone, S., Su, L., Savoldo, B., & Dotti, G. (2021). Preclinical Evaluation of B7-H3-Specific Chimeric Antigen Receptor T cells for the Treatment of Acute Myeloid Leukemia. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-2540 Cite
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MGST1 Is a Redox-Sensitive Repressor of Ferroptosis in Pancreatic Cancer Cells

Scientists showed a key role of MGST1 in inhibiting ferroptosis in cell cultures and mouse xenograft models. Ferroptosis activators induced MGST1 upregulation in human PDAC cell lines in an NFE2L2-dependent manner.
[Cell Chemical Biology]
Kuang, F., Liu, J., Xie, Y., Tang, D., & Kang, R. (2021). MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2021.01.006 Cite
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The PSMA Targeting Half-Life Extended BiTE® Therapy AMG 160 Has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-Resistant Prostate Cancer

Researchers developed AMG 160, a half-life extended bispecific T-cell engager (HLE BiTE®) immuno-oncology therapy that bound prostate-specific membrane antigen (PSMA) on prostate cancer cells and CD3 on T cells for treatment of metastatic castration-resistant prostate cancer.
[Clinical Cancer Research]
Deegen, P., Thomas, O., Nolan-Stevaux, O., Li, S., Wahl, J., Bogner, P., Aeffner, F., Friedrich, M., Liao, M. Z., Matthes, K., Rau, D., Rattel, B., Raum, T., Kufer, P., Coxon, A., & Bailis, J. M. (2021). The PSMA Targeting Half-Life Extended BiTE® Therapy AMG 160 Has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-Resistant Prostate Cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3725 Cite
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Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis

Scientists provided strong evidence that epithelial-to-mesenchymal transition (EMT) was orchestrated by coordinated expression of several EMT- transcription factors and established ZEB1 as a key master regulator of EMT and metastasis in breast cancer.
[Molecular Cancer Research]
Addison, J. B., Voronkova, M. A., Fugett, J. H., Lin, C.-C., Linville, N. C., Trinh, B., Livengood, R. H., Smolkin, M. B., Schaller, M. D., Ruppert, J. M., Pugacheva, E. N., Creighton, C. J., & Ivanov, A. V. (2021). Functional hierarchy and cooperation of EMT master transcription factors in breast cancer metastasis. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0532 Cite
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Inhibition of Endothelin-B Receptor Signaling Synergizes with MAPK Pathway Inhibitors in BRAF Mutated Melanoma

The authors demonstrated that the endothelin-endothelin receptor B signaling pathway conferred resistance to MAPK pathway inhibitors in BRAF mutated melanoma.
[Oncogene]
Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma | Oncogene. (n.d.). Retrieved January 27, 2021, from https://www.nature.com/articles/s41388-020-01628-x Cite
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Circulating Extracellular Vesicles Release Oncogenic miR-424 in Experimental Models and Patients with Aggressive Prostate Cancer

Scientists investigated the release of miR-424 in circulating small extracellular vesicles or exosomes from prostate cancer patients and assessed the functional implications in multiple experimental models.
[Communications Biology]
Albino, D., Falcione, M., Uboldi, V., Temilola, D. O., Sandrini, G., Merulla, J., Civenni, G., Kokanovic, A., Stürchler, A., Shinde, D., Garofalo, M., Mestre, R. P., Constâncio, V., Wium, M., Burrello, J., Baranzini, N., Grimaldi, A., Theurillat, J.-P., Bossi, D., … Carbone, G. M. (2021). Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-020-01642-5 Cite
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Long Noncoding RNA SNHG1 Promotes Human Prostate Cancer Progression by Sponging miR-383-5p

Investigators found the level of small nucleolar RNA host gene 1 (SNHG1) was significantly upregulated in prostate cancer tissues and cells. Knockdown of SNHG1 significantly suppressed proliferation, migration and invasion and promoted cell apoptosis in prostate cancer cells.
[Anti-Cancer Drugs]
Huang, G., Guo, X., & Yang, H. (2021). Long noncoding RNA SNHG1 promotes human prostate cancer progression by sponging miR-383-5p. Anti-Cancer Drugs, Publish Ahead of Print. https://doi.org/10.1097/CAD.0000000000000916 Cite
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