Targeting the Tetraspanin CD81 Reduces Cancer Invasion and Metastasis

Scientists showed that a unique anti-human CD81 antibody (5A6) effectively halted invasion of TNBC cell lines. They demonstrated that 5A6 induced CD81 clustering at the cell membrane and implicated JAM-A protein in the ability of this antibody to inhibit tumor cell invasion and migration.
[Proceedings of the National Academy of Sciences of the United States of America]
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Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer

The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.
[Molecular Therapy-Nucleic Acids]
Sun, Z., Sun, D., Feng, Y., Zhang, B., Sun, P., Zhou, B., Du, L., Wang, Y., Fan, Z., Yang, J., Li, Y., Hu, S., & Zhan, H. (2021). Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.06.001 Cite
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Synergistic Effect of Toosendanin and Regorafenib against Cell Proliferation and Migration by Regulating WWOX Signaling Pathway in Hepatocellular Carcinoma

Scientists identified that TSN and RGF combination synergistically inhibited the proliferation and migration of MHCC-97L cells.
[Phytotherapy Research]
Yang, T., Huo, J., Xu, R., & Zhang, Y. (n.d.). Synergistic effect of toosendanin and regorafenib against cell proliferation and migration by regulating WWOX signaling pathway in hepatocellular carcinoma. Phytotherapy Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/ptr.7174 Cite
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Darolutamide Potentiates the Antitumor Efficacy of a PSMA-Targeted Thorium-227 Conjugate (PSMA-TTC) by a Dual Mode-of-Action in Prostate Cancer Models

Researchers evaluated the efficacy and explored the mode-of-action of the PSMA-TTC BAY 2315497, an antibody-based targeted alpha therapy, in combination with the androgen receptor inhibitor darolutamide.
[Clinical Cancer Research]
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Hexose-6-Phosphate Dehydrogenase Blockade Reverses Prostate Cancer Drug Resistance in Xenograft Models by Glucocorticoid Inactivation

Researchers showed that up-regulation of hexose-6-phosphate dehydrogenase protein occured in prostate cancer tissues of men treated with enzalutamide, human-derived cell lines, and patient-derived prostate tissues treated ex vivo with enzalutamide.
[Science Advances]
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A Prometastatic Splicing Program Regulated by SNRPA1 Interactions with Structured RNA Elements

Researchers established a noncanonical function for small nuclear ribonucleoprotein polypeptide A′ (SNRPA1) and a previously unknown RNA structural code that regulated alternative splicing, and found that this SNRPA1-mediated pathway acted as a promoter of breast cancer metastasis.
[Science]
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The Loss of SHMT2 Mediates 5-Fluorouracil Chemoresistance in Colorectal Cancer by Upregulating Autophagy

Scientists identified serine hydroxymethyltransferase-2 (SHMT2) as a critical regulator of 5-FU chemoresistance in colorectal cancer.
[Oncogene]
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A Novel Dual HDAC and HSP90 Inhibitor, MPT0G449, Downregulates Oncogenic Pathways in Human Acute Leukemia In Vitro and In Vivo

Scientists suggested that the dual inhibition of HDAC and HSP90 could suppress the expression of oncogenic pathways in acute leukemia, and MPT0G449 represented a novel therapeutic for anticancer treatment.
[Oncogenesis]
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Avasopasem Manganese Synergizes with Hypofractionated Radiation to Ablate Tumors through the Generation of Hydrogen Peroxide

In vitro non-small lung cancer and mammary adenocarcinoma models showed that auranofin-induced inhibition of glutathione- and thioredoxin-dependent hydrogen peroxide metabolism selectively enhanced Avasopasem manganese-induced killing of cancer cells compared to normal cells.
[Science Translational Medicine]
Sishc, B. J., Ding, L., Nam, T.-K., Heer, C. D., Rodman, S. N., Schoenfeld, J. D., Fath, M. A., Saha, D., Pulliam, C. F., Langen, B., Beardsley, R. A., Riley, D. P., Keene, J. L., Spitz, D. R., & Story, M. D. (2021). Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide. Science Translational Medicine, 13(593). https://doi.org/10.1126/scitranslmed.abb3768 Cite
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Biomechanical Regulation of Breast Cancer Metastasis and Progression

The authors investigated the role of mechanical forces in altering the chemoresistance, proliferation and metastasis of breast cancer cells and used high throughput mechanobiological screens to identify pathways that could be targeted to reduce the effects of load.
[Scientific Reports]
Spencer, A., Sligar, A. D., Chavarria, D., Lee, J., Choksi, D., Patil, N. P., Lee, H., Veith, A. P., Riley, W. J., Desai, S., Abbaspour, A., Singeetham, R., & Baker, A. B. (2021). Biomechanical regulation of breast cancer metastasis and progression. Scientific Reports, 11(1), 9838. https://doi.org/10.1038/s41598-021-89288-z Cite
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Hypoxia-Sensing CAR T Cells Provide Safety and Efficacy in Treating Solid Tumors

Using murine xenograft models, scientists demonstrated that, despite widespread expression of ErbB receptors in healthy organs, the approach provided anti-tumor efficacy without off-tumor toxicity.
[Cell Reports Medicine]
Kosti, P., Opzoomer, J. W., Larios-Martinez, K. I., Henley-Smith, R., Scudamore, C. L., Okesola, M., Taher, M. Y. M., Davies, D. M., Muliaditan, T., Larcombe-Young, D., Woodman, N., Gillett, C. E., Thavaraj, S., Maher, J., & Arnold, J. N. (2021). Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors. Cell Reports Medicine, 0(0). https://doi.org/10.1016/j.xcrm.2021.100227 Cite
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