Discoidin Domain Receptor 1 Promotes Hepatocellular Carcinoma Progression through Modulation of SLC1A5 and the mTORC1 Signaling Pathway

Scientists showed that the expression of DDR1 was significantly increased in HCC and was related to a poor clinical prognosis.
[Cellular Oncology]
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Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer

Integrated copy number aberration and gene expression analysis of primary high-risk prostate cancer identified the AZIN1 gene as a novel driver of metastatic progression, by altering collagen subunit expression.
[Molecular Cancer Research]
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Therapeutic Effects of TM4SF5-Targeting Chimeric and Humanized Monoclonal Antibodies in Hepatocellular and Colon Cancer Models

The authors evaluated the effects of chimeric Ab27 using cancer cells expressing endogenous transmembrane 4 L six family member 5 (TM4SF5) or stably overexpressing TM4SF5 in vivo and in vitro.
[Molecular Therapy-Oncolytics]
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Notch Pathway Inhibition Mediated by Arsenic Trioxide Depletes Tumor Initiating Cells in Small Cell Lung Cancer

Researchers demonstrated that As2O3 had a remarkable inhibitory effect on tumor initiating cells of small cell lung cancer both in vitro and in vivo, and the mechanism might have involved the down-regulation of Notch pathway
[Molecular Biology Reports]
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A BAFF Ligand-Based CAR-T Cell Targeting Three Receptors and Multiple B Cell Cancers

Investigators developed a B cell-activating factor (BAFF) ligand-based CAR and generated BAFF CAR-T cells using a non-viral gene delivery method.
[Nature Communications]
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Combination of Tucatinib and Neural Stem Cells Secreting Anti-HER2 Antibody Prolongs Survival of Mice with Metastatic Brain Cancer

The authors engineered the highly migratory and brain tumor tropic human neural stem cells LM008 to continuously secrete high amounts of functional, stable, full-length antibodies against human epidermal growth factor receptor 2 (HER2) without compromising the stemness of LM008 cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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Clonal Dynamics of BRAF-Driven Drug Resistance in EGFR-Mutant Lung Cancer

Complementary functional analyses of polyclonal EGFR-mutant cell pools showed a dose-dependent enrichment of BRAFV600E and a loss of EGFR inhibitor susceptibility.
[npj Precision Oncology]
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Excellent Effects and Possible Mechanisms of Action of a New Antibody–Drug Conjugate against EGFR-Positive Triple-Negative Breast Cancer

Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.
[Military Medical Research]
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Triple Targeting of Breast Tumors Driven by Hormonal Receptors and HER2

Investigators tested the activity of co-targeting of estrogen receptor, HER2, and cyclin-dependent kinases 4/6 therapy with tucatinib, palbociclib, and fulvestrant in HR+/HER2+ human breast tumor cell lines and xenograft models.
[Molecular Cancer therapeutics]
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Dynamic Prostate Cancer Transcriptome Analysis Delineates the Trajectory to Disease Progression

Scientists generated a comprehensive prostate cancer transcriptome atlas that described the roadmap to tumor progression in a qualitative and quantitative manner. Using patient-derived xenograft models, they functionally validated their observations and add single-cell resolution.
[Nature Communications]
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Mitochondrial Complex I Inhibitors Suppress Tumor Growth through Concomitant Acidification of the Intra- and Extracellular Environment

The authors investigated the anti-cancer activity of the mitochondrial complex I inhibitor intervenolin, which modulated the tumor microenvironment independent of energy depletion.
[iScience]
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