Metagenomics Studies for the Diagnosis and Treatment of Prostate Cancer

The authors question the role of metagenomics studies in the diagnosis and treatment of prostate cancer (PC). Based on next-generation sequencing-generated data, Proteobacteria, Firmicutes, Actinobacteria, and Bacteriodetes are the nine frequent phyla detected in a PC sample.
[Prostate]
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Understanding and Targeting Prostate Cancer Cell Heterogeneity and Plasticity

Scientists discuss prostate cancer (PCa) from the perspective of an abnormal organ development and deregulated cellular differentiation, and discuss the luminal progenitor cells as the likely cells of origin for PCa.
[Seminars in Cancer Biology]
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NUAK Family Kinase 2 Is a Novel Therapeutic Target for Prostate Cancer

Scientists found that NUAK family kinase 2 (NUAK2) expression was elevated in prostate cancer and metastatic castration resistant PC versus normal tissue, and expression correlated with an increased risk of metastasis.
[Molecular Carcinogenesis]
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MYB Interacts with Androgen Receptor, Sustains Its Ligand-Independent Activation and Promotes Castration Resistance in Prostate Cancer

Scientists investigated MYB-androgen receptor crosstalk and its functional significance. MYB-overexpressing prostate cancer cells exhibited greater tumorigenicity when implanted orthotopically and quickly regained growth following castration leading to shorter mice survival.
[British Journal of Cancer]
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Imatinib Mesylate Inhibits Androgen-Independent PC-3 Cell Viability, Proliferation, Migration, and Tumor Growth by Targeting Platelet-Derived Growth Factor Receptor-α

The authors examined the role of platelet-derived growth factor receptors (PDGFRs) in androgen-independent PC-3 cells and found that PDGFRα was upregulated in androgen-independent PC-3 cells compared with normal prostate epithelial cells.
[Life Sciences]
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Extracellular Vesicles as a Source of Prostate Cancer Biomarkers in Liquid Biopsies: A Decade of Research

Prostate cancer is a global cancer burden and considerable effort has been made through the years to identify biomarkers for the disease. Investigators present the knowledge acquired during the last decade that constitutes a solid basis for the future development of liquid biopsy tests for prostate cancer.
[British Journal of Cancer]
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Non-Invasive Urine Metabolomics of Prostate Cancer and Its Therapeutic Approaches: A Current Scenario and Future Perspective

The authors provide a concise overview of the prostate cancer metabolomics-based potential discriminating molecules in urine samples using nuclear magnetic resonance spectroscopy and mass spectrometry.
[Expert Review of Proteomics]
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lncRNA Prostate Cancer-Associated Transcript 18 Upregulates Activating Transcription Factor 7 to Prevent Metastasis of Triple-Negative Breast Cancer via Sponging miR-103a-3p

Prostate cancer-associated transcript 18 (PCAT18) was expressed at low levels in TNBC, and PCAT18 could sponge miR-103a-3p and promote activating transcription factor 7 expression, resulting in prevention of TNBC metastasis.
[Bioengineered]
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TCF7L1 Regulates Cytokine Response and Neuroendocrine Differentiation of Prostate Cancer

Researchers identified androgen-deprivation therapy-mediated upregulation of transcription factor 7 like 1 (TCF7L1), which increased the cytokine response and enhanced neuroendocrine differentiation of prostate cancer through interleukin-8/C-X-C motif chemokine receptor type 2 signaling activation.
[Oncogenesis]
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Prognostic and Therapeutic Significance of COP9 Signalosome Subunit CSN5 in Prostate Cancer

Deregulation of CSN5, a putative androgen receptor (AR), could affect diverse cellular functions that contribute to tumor development. Inhibition of CSN5 repressed metabolic pathways, including oxidative phosphorylation and glycolysis in AR-negative prostate cancer cells.
[Oncogene]
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PCK1 Regulates Neuroendocrine Differentiation in a Positive Feedback Loop of LIF/ZBTB46 Signaling in Castration-Resistant Prostate Cancer

Investigators identified that PCK1 was a pivotal regulator in therapy-induced neuroendocrine differentiation of prostate cancer through a LIF/ZBTB46-driven glucose metabolism pathway.
[British Journal of Cancer]
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