prostate cancer

[Journal of Natural Products] Physachenolide C is a 17β-hydroxywithanolide natural product with a unique anticancer potential, as it exhibits potent and selective in vitro antiproliferative activity against prostate cancer (PC) cells. Researchers explored the effect of ring A/B modifications of physachenolide C on these biological activities.

[Drug Delivery and Translational Research] Curmumin (CRN)-NLC nanoparticles were administrated to nude mice with LNCaP prostate cancer xenografts and demonstrated substantial tumor volume suppression with no weight loss compared to pure CRN.

[Clinical Epigenetics] Ten–eleven translocation methylcytosine dioxygenase 1 (TET1) is involved in DNA demethylation and transcriptional regulation, plays a key role in the maintenance of stem cell pluripotency, and is dysregulated in malignant cells. Researchers analyzed TET1 expression in prostate cancer.

[Prostate] The authors question the role of metagenomics studies in the diagnosis and treatment of prostate cancer (PC). Based on next-generation sequencing-generated data, Proteobacteria, Firmicutes, Actinobacteria, and Bacteriodetes are the nine frequent phyla detected in a PC sample.

[Seminars in Cancer Biology] Scientists discuss prostate cancer (PCa) from the perspective of an abnormal organ development and deregulated cellular differentiation, and discuss the luminal progenitor cells as the likely cells of origin for PCa.

[Molecular Carcinogenesis] Scientists found that NUAK family kinase 2 (NUAK2) expression was elevated in prostate cancer and metastatic castration resistant PC versus normal tissue, and expression correlated with an increased risk of metastasis.