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prostate cancer

METTL14 Promotes Prostate Tumorigenesis by Inhibiting THBS1 via an m6A-YTHDF2-Dependent Mechanism

[Cell Death Discovery] The authors found that knocking down METTL14 inhibited tumor proliferation both in vitro and in vivo.

Carbon Sources and Pathways for Citrate Secreted by Human Prostate Cancer Cells Determined by NMR Tracing and Metabolic Modeling

[Proceedings of the National Academy of Sciences of the United States of America] Scientists mapped potential pathways for citrate carbons in the human prostate cancer metastasis cell lines LNCaP and VCaP, for which they first established that they secrete citrate.

High-Dose-Androgen-Induced Autophagic Cell Death to Suppress the Enzalutamide-Resistant Prostate Cancer Growth via Altering the circRNA-BCL2/miRNA-198/AMBRA1 Signaling

[Cell Death Discovery] In vitro and in vivo data provided new insights for understanding the mechanisms underlying high-dose-dihydrotestosterone suppression of the enzalutamide-resistant CRPC cell growth, supporting a potential therapy using high-dose-androgens to suppress CRPC progression in the future.

The mTOR Chromatin-Bound Interactome in Prostate Cancer

[Cell Reports] Comprehensive mapping of the mTOR chromatin-bound interactome in both androgen-dependent and -independent cellular models of prostate cancer identified a conserved 67-protein interaction network enriched for chromatin modifiers, transcription factors, and SUMOylation machinery.

Histone Methyltransferase KMT2C Plays an Oncogenic Role in Prostate Cancer

[Journal of Cancer Research and Clinical Oncology] The authors assessed the function of KMT2C in prostate cancer cell proliferation, colony formation, and migration.

The Marine Factor 3,5-Dihydroxy-4-Methoxybenzyl Alcohol Suppresses Growth, Migration and Invasion and Stimulates Death of Metastatic Human Prostate Cancer Cells: Targeting Diverse Signaling Processes

[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.

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