prostate cancer

[Stem Cells and Development] Scientists reported that reduced death-associated protein kinase 1 (DAPK1) expression promoted stem cell-like characteristics of prostate cancer cells through activating zinc finger E-box binding homeobox-1 (ZEB1) via Hippo/YAP signaling pathway.

[Gestalt Diagnostics (Business Wire, Inc.)] Gestalt Diagnostics and Deep Bio announced their strategic relationship on the development of an integrated workflow for pathologists to use Artificial Intelligence algorithms directly within Gestalt's PathFlow® platform. Deep Bio's algorithm analyzes whole slide images of H&E-stained prostate core needle biopsy tissue specimens to detect and classify prostate cancer.

[Cell Death & Disease] The hsa_circ_0001747 signature was selected for further experimental verification in vitro and in vivo, which showed that downregulated hsa_circ_0001747 might facilitate prostate cancer via augmenting autophagy.

[Nature Reviews Urology] The theory of senescence as a mechanism for prostate disease has a number of clinical implications and could offer opportunities for targeting in the future.

[Scientific Reports] The authors conjugated a Prostate-Specific Membrane Antigen (PSMA) inhibitor to the apoptosis-inducing human protease Granzyme B and the potent Pseudomonas exotoxin protein toxin fragment, PE35.

[Scientific Reports] Researchers investigated the role of Hedgehog-GLI signaling in sustaining androgen-independent growth of prostate cancer cells.