Effect of the Mitochondrial Transaminase (GOT2) on Membrane Potential Sensitive Respiration in Mitochondria of Differentiated C2C12 Muscle Cells

To assess the effect of the mitochondrial transaminase, glutamic oxaloacetic transaminase (GOT2) on complex II respiration and to determine the effect in intact cells and isolated mitochondria, researchers performed respiratory and metabolic studies in wildtype and CRISPR-generated GOT2 knockdown C2C12 myocytes.