Long Noncoding RNA SNHG1 Promotes Human Prostate Cancer Progression by Sponging miR-383-5p

Investigators found the level of small nucleolar RNA host gene 1 (SNHG1) was significantly upregulated in prostate cancer tissues and cells. Knockdown of SNHG1 significantly suppressed proliferation, migration and invasion and promoted cell apoptosis in prostate cancer cells.
[Anti-Cancer Drugs]
Huang, G., Guo, X., & Yang, H. (2021). Long noncoding RNA SNHG1 promotes human prostate cancer progression by sponging miR-383-5p. Anti-Cancer Drugs, Publish Ahead of Print. https://doi.org/10.1097/CAD.0000000000000916 Cite
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Down Regulation of U2AF1 Promotes ARV7 Splicing and Prostate Cancer Progression

Scientists investigated the roles of U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) in the resistance to anti-androgen treatment in prostate cancer and its underlying mechanism.
[Biochemical and Biophysical Research Communications]
Cao, H., Wang, D., Gao, R., Chen, L., & Feng, Y. (2021). Down regulation of U2AF1 promotes ARV7 splicing and prostate cancer progression. Biochemical and Biophysical Research Communications, 541, 56–62. https://doi.org/10.1016/j.bbrc.2020.12.111 Cite
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Regulation of Carcinogenesis and Mediation through Wnt/β-Catenin Signaling by 3,3′-Diindolylmethane in an Enzalutamide-Resistant Prostate Cancer Cell Line

To investigate whether combined treatment with Enzalutamide (ENZ) and 3,3′-diindolylmethane (DIM) could overcome ENZ resistance by regulating Wnt signaling to inhibit androgen receptor signaling and EMT in ENZ-resistant prostate cancer cells, 22Rv1 cells were cultured in normal medium and treated with ENZ, DIM, and DIM with ENZ.
[Scientific Reports]
Tsao, C.-W., Li, J.-S., Lin, Y.-W., Wu, S.-T., Cha, T.-L., & Liu, C.-Y. (2021). Regulation of carcinogenesis and mediation through Wnt/β-catenin signaling by 3,3′-diindolylmethane in an enzalutamide-resistant prostate cancer cell line. Scientific Reports, 11(1), 1239. https://doi.org/10.1038/s41598-020-80519-3 Cite
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Melatonin Interrupts Osteoclast Functioning and Suppresses Tumor-Secreted RANKL Expression: Implications for Bone Metastases

Investigators observed that melatonin inhibited RANKL production in lung and prostate cancer cells by downregulating the p38 MAPK pathway, which in turn prevented cancer-associated osteoclast differentiation.
[Oncogene]
Liu, P.-I., Chang, A.-C., Lai, J.-L., Lin, T.-H., Tsai, C.-H., Chen, P.-C., Jiang, Y.-J., Lin, L.-W., Huang, W.-C., Yang, S.-F., & Tang, C.-H. (2021). Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01613-4 Cite
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CD117/C-Kit Defines a Prostate CSC-Like Subpopulation Driving Progression and TKI Resistance

To determine how CD117 expression and activation by its ligand stem cell factor alters prostate cancer aggressiveness, researchers used C4-2 and PC3-mm human prostate cancer cells, which contained a CD117+ subpopulation.
[Scientific Reports]
Harris, K. S., Shi, L., Foster, B. M., Mobley, M. E., Elliott, P. L., Song, C. J., Watabe, K., Langefeld, C. D., & Kerr, B. A. (2021). CD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance. Scientific Reports, 11(1), 1465. https://doi.org/10.1038/s41598-021-81126-6 Cite
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Post-Transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

Scientists showed that microRNA-194 (miR-194) is a regulator of epithelial-neuroendocrine (NE) transdifferentiation. In clinical prostate cancer (PC) samples, miR-194 expression and activity were elevated in NEPC and inversely correlated with androgen receptor signaling.
[Cell Reports]
Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., Bert, A. G., Winter, J. M., Iggo, R., Das, R., Obinata, D., Sandhu, S., Risbridger, G. P., Taylor, R. A., Lawrence, M. G., Butler, L. M., Zoubeidi, A., Gregory, P. A., Tilley, W. D., … Selth, L. A. (2021). Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer. Cell Reports, 34(1). https://doi.org/10.1016/j.celrep.2020.108585 Cite
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Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer Cellular Migration and Invasion

Investigators performed a direct, unbiased chemical genetic screen to identify pro-viral integration site for Moloney murine leukemia virus-1 (PIM1) substrates in prostate cancer cells.
[Communications Biology]
Ledet, R. J., Ruff, S. E., Wang, Y., Nayak, S., Schneider, J. A., Ueberheide, B., Logan, S. K., & Garabedian, M. J. (2021). Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion. Communications Biology, 4(1), 1–12. https://doi.org/10.1038/s42003-020-01528-6 Cite
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Reciprocal Interactions between Tumour Cell Populations Enhance Growth and Reduce Radiation Sensitivity in Prostate Cancer

Researchers evaluated whether interactions between heterogenous populations could impact growth and response to radiotherapy in prostate cancer.
[Communications Biology]
Paczkowski, M., Kretzschmar, W. W., Markelc, B., Liu, S. K., Kunz-Schughart, L. A., Harris, A. L., Partridge, M., Byrne, H. M., & Kannan, P. (2021). Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-020-01529-5 Cite
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Targeting Therapy-Resistant Prostate Cancer via a Direct Inhibitor of the Human Heat Shock Transcription Factor 1

Direct targeted HSF1 inhibitor robustly inhibited the heat shock factor 1 cancer gene signature and prostate cancer cell proliferation. It potently attenuated tumor progression in four therapy-resistant prostate cancer animal models, including an neuroendocrine prostate cancer model, where it caused profound tumor regression.
[Science Translational Medicine]
Dong, B., Jaeger, A. M., Hughes, P. F., Loiselle, D. R., Hauck, J. S., Fu, Y., Haystead, T. A., Huang, J., & Thiele, D. J. (2020). Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Science Translational Medicine, 12(574). https://doi.org/10.1126/scitranslmed.abb5647 Cite
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Enzalutamide Response in a Panel of Prostate Cancer Cell Lines Reveals a Role for Glucocorticoid Receptor in Enzalutamide Resistant Disease

Representative in vitro model systems that accurately model response to therapy and allow the identification of new targets are important for improving the treatment of prostate cancer. Scientists describe molecular characterization and drug testing in a panel of 20 prostate cancer cell lines.
[Scientific Reports]
Smith, R., Liu, M., Liby, T., Bayani, N., Bucher, E., Chiotti, K., Derrick, D., Chauchereau, A., Heiser, L., Alumkal, J., Feiler, H., Carroll, P., & Korkola, J. E. (2020). Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant disease. Scientific Reports, 10(1), 21750. https://doi.org/10.1038/s41598-020-78798-x Cite
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A Review of the Effects and Molecular Mechanisms of Dimethylcurcumin (ASC-J9) on Androgen Receptor-Related Diseases

The effects and molecular mechanisms of ASC‐J9 on various AR‐associated diseases are summarized. Importantly, the effects of ASC‐J9 and AR antagonists enzalutamide/bicalutamide on prostate cancer are compared in detail and crucial differences are highlighted.
[Chemical Biology & Drug Design]
Hu, H., Zhou, H., & Xu, D. (n.d.). A review of the effects and molecular mechanisms of dimethylcurcumin (ASC-J9) on androgen receptor-related diseases. Chemical Biology & Drug Design, n/a(n/a). https://doi.org/https://doi.org/10.1111/cbdd.13811 Cite
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