Tag Archives: prostate cells

Bortezomib Potentiates Antitumor Activity of Mitoxantrone through Dampening Wnt/β-Catenin Signal Pathway in Prostate Cancer Cells

Researchers determined the anticancer effects of a combination of bortezomib and mitoxantrone by apoptosis and proliferation assay in vivo and in vitro.
[BMC Cancer]
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AXL Cooperates with EGFR to Mediate Neutrophil Elastase-Induced Migration of Prostate Cancer Cells

Scientists reported that neutrophil elastase triggered dose-dependent ERK signaling and cell migration in a panel of prostate cell lines representing the spectrum of prostate cell malignancy.
[iScience]
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OXER1 Mediates Testosterone-Induced Calcium Responses in Prostate Cancer Cells

The authors reported that testosterone, independently of the presence of the classical androgen receptor, rapidly increased intracellular calcium from calcium stores, through the oxoeicosanoid receptor 1 (OXER1) and a signaling cascade that triggered calcium release from the endoplasmic reticulum.
[Molecular and Cellular Endocrinology]
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Novel Chemotherapeutic Agent FX-9 Activates NF-κB Signaling and Induces G1 Phase Arrest by Activating CDKN1A in a Human Prostate Cancer Cell Line

Investigators conducted microarray gene expression analysis and compared FX-9 exposed and unexposed prostate cancer cells, followed by pathway analysis and gene annotation to functional processes.
[BMC Cancer]
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GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer

The authors showed that GLI3, a key SHH pathway effector, was transcriptionally upregulated during androgen deprivation and posttranslationally stabilized in prostate cancer cells by mutation of speckle-type POZ protein.
[Molecular Cancer Research]
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Synthesis of 3′- O-Alkyl Homologues and a Biotin Probe of Isorhamnetin and Evaluation of Cytotoxic Efficacy on Cancer Cells

Investigators synthesized 3′- O -substituted quercetin as isorhamnetin analogues and evaluated the growth inhibitory activity of these derivatives on breast, colon and prostate cancer cell lines.
[Chemistry & Biodiversity]
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Discovery of a New Candidate Drug to Overcome Cabazitaxel-Resistant Gene Signature in Castration-Resistant Prostate Cancer by In Silico Screening

Researchers used screening tests for candidate drugs targeting cabazitaxel (CBZ)-resistant-related gene expression and identified pimozide as a potential candidate for overcoming CBZ resistance in castration-resistant prostate cancer.
[Prostate Cancer and Prostatic Diseases]
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Synthesis and Biological Evaluation of 1,2, 3-Triazole Hybrids of 4-Methoxy Ethyl Cinnamate Isolated from Hedychium spicatum (Sm) Rhizomes: Identification of Antiproliferative Lead Actives against Prostate Cancer

Among the compounds tested, compounds 9i and 9k potently arrested proliferation of DU-145, the prostate cancer cell line.
[Natural Product Research]
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Curcumol Inhibits the Malignant Progression of Prostate Cancer and Regulates the PDK1/AKT/mTOR Pathway by Targeting miR-9

Researchers analyzed the effect of curcumol on prostate cancer and identify its possible internal regulatory pathway using in vitro cell culture and in vivo tumor model experiments.
[Oncology Reports]
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Bergamottin a CYP3A Inhibitor Found in Grapefruit Juice Inhibits Prostate Cancer Cell Growth by Downregulating Androgen Receptor Signaling and Promoting G0/G1 Cell Cycle Block and Apoptosis

Researchers observed that bergamottin reduced prostate cancer cell growth by decreasing both total and nuclear AR reducing downstream AR signaling.
[PLOS One]
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In Vitro and In Vivo Comparative Study of a Novel 68Ga-Labeled PSMA-Targeted Inhibitor and 68Ga-PSMA-11

The authors designed and synthesized a new prostate-specific membrane antigen-targeted radiotracer, 68Ga-SC691, with high affinity for prostate cancer cells and excellent pharmacokinetics.
[Scientific Reports]
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