Sox2 Is Necessary for Androgen Ablation-Induced Neuroendocrine Differentiation from Pten Null Sca-1+/sup> Prostate Luminal Cells

Researchers provide direct genetic evidence that Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation of Pten null prostate adenocarcinoma. They corroborate that the lineage status of the prostate cancer cells is a determinant for its propensity to exhibit lineage plasticity, and support that the intrinsic features of cell-of-origin for prostate cancers can dictate their clinical behaviors.
[Oncogene]
Kwon, O.-J., Zhang, L., Jia, D., & Xin, L. (2020). Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation from Pten null Sca-1 + prostate luminal cells. Oncogene, 1–12. https://doi.org/10.1038/s41388-020-01526-2 Cite
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

To discover modulators of androgen receptor (AR)-variant activity, investigtors used a lysate-based small-molecule microarray assay and identified KI-ARv-03 as an AR-variant complex binder that reduced AR-driven transcription and proliferation in prostate cancer cells.
[Cell Chemical Biology]
Richters, A., Doyle, S. K., Freeman, D. B., Lee, C., Leifer, B. S., Jagannathan, S., Kabinger, F., Koren, J. V., Struntz, N. B., Urgiles, J., Stagg, R. A., Curtin, B. H., Chatterjee, D., Mathea, S., Mikochik, P. J., Hopkins, T. D., Gao, H., Branch, J., Xin, H., … Koehler, A. N. (2020). Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2020.10.001 Cite
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Loss of RBMS1 as a Regulatory Target of miR-106b Influences Cell Growth, Gap Closing and Colony Forming in Prostate Carcinoma

Scientists demonstrated for the first time a miR-106b dependent downregulation of RBMS1 in prostate carcinoma. Additionally, they showed new tumour suppressive properties of RBMS1 whose observed loss may further elucidate the development of prostate carcinoma.
[Scientific Reports]
Dankert, J. T., Wiesehöfer, M., Wach, S., Czyrnik, E. D., & Wennemuth, G. (2020). Loss of RBMS1 as a regulatory target of miR-106b influences cell growth, gap closing and colony forming in prostate carcinoma. Scientific Reports, 10(1), 18022. https://doi.org/10.1038/s41598-020-75083-9 Cite
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Neuronal Calcitonin Gene-Related Peptide Promotes Prostate Tumor Growth in the Bone Microenvironment

Calcitonin gene-related peptide treatment activated extracellular signal-regulated kinases/Signal transducer and activator of transcription 3 signaling in prostate cancer cells.
[Peptides]
Zhu, W., Sheng, D., Shao, Y., Zhang, Q., & Peng, Y. (2021). Neuronal calcitonin gene-related peptide promotes prostate tumor growth in the bone microenvironment. Peptides, 135, 170423. https://doi.org/10.1016/j.peptides.2020.170423 Cite
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Rosuvastatin Inhibit Spheroid Formation and Epithelial-Mesenchymal Transition (EMT) in Prostate Cancer PC-3 Cell Line

PC-3 cells were cultured in adherence and/or spheroid culture system. The cells were treated with different concentrations of Rosuvastatin. After 96 hours, the cell proliferation, viability, type and number of spheroids, the expression of E-Cadherin, Vimentin and Zeb-1 were analyzed.
[Molecular Biology Reports]
Deezagi, A., & Safari, N. (2020). Rosuvastatin inhibit spheroid formation and epithelial–mesenchymal transition (EMT) in prostate cancer PC-3 cell line. Molecular Biology Reports. https://doi.org/10.1007/s11033-020-05918-1 Cite
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The Alpha-1,2 Fucosylated Tubule System of DU145 Prostate Cancer Cells Is Derived from a Partially Fragmented Golgi Complex and Its Formation Is Actin-Dependent

The authors present evidence that in the prostate cancer cell line DU145, the tubules arise in actively growing cells from vesicles in the medial and trans elements of a partially fragmented Golgi complex, while in not actively growing cells the tubules become completely independent from the Golgi complex.
[Experimental Cell Research]
Nolfi, D., Capone, A., Rosati, F., & Della Giovampaola, C. (2020). The alpha-1,2 fucosylated tubule system of DU145 prostate cancer cells is derived from a partially fragmented Golgi complex and its formation is actin-dependent. Experimental Cell Research, 396(2), 112324. https://doi.org/10.1016/j.yexcr.2020.112324 Cite
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ROS-Mediated Genotoxic Stress Is Involved in NaAsO2-Induced Cell Cycle Arrest, Stemness Enhancement and Chemoresistance of Prostate Cancer Cells in a p53-Independent Manner

The authors suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.
[Ecotoxicology and Environmental Safety]
Zhang, Z.-H., Hong, Q., Zhang, Z.-C., Xing, W.-Y., Xu, S., Tian, Q.-X., Ye, Q.-L., Wang, H., Yu, D.-X., Xie, D.-D., & Xu, D.-X. (2021). ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. Ecotoxicology and Environmental Safety, 208, 111436. https://doi.org/10.1016/j.ecoenv.2020.111436 Cite
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In Vivo Imaging of Long-Term Accumulation of Cancer-Derived Exosomes using a BRET-Based Reporter

Transplantation of CD63-Antares2-expressing prostate cancer cells into mice allowed determining the amount of cancer-derived exosomes released from primary tumors into the bloodstream and visualizing the long-term homing behavior of exosomes to their target organs or tissues.
[Scientific Reports]
Hikita, T., Miyata, M., Watanabe, R., & Oneyama, C. (2020). In vivo imaging of long-term accumulation of cancer-derived exosomes using a BRET-based reporter. Scientific Reports, 10(1), 16616. https://doi.org/10.1038/s41598-020-73580-5 Cite
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SFMBT2-Mediated Infiltration of Preadipocytes and TAMs in Prostate Cancer

Researchers investigated whether the down-regulation of Scm-like with four mbt domains 2 (SFMBT2) regulated the infiltration of preadipocytes and tumor-associated macrophages in prostate cancer.
[Cancers]
Gwak, J., Jeong, H., Lee, K., Shin, J. Y., Sim, T., Na, J., Kim, J., & Ju, B.-G. (2020). SFMBT2-Mediated Infiltration of Preadipocytes and TAMs in Prostate Cancer. Cancers, 12(9), 2718. https://doi.org/10.3390/cancers12092718 Cite
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Isolation and Characterization of Castration-Resistant Prostate Cancer LNCaP95 Clones

Investigators attempted to identify a LNCaP95 clone that would be useful for evaluating therapies for their effectiveness against enzalutamide-resistant prostate cancer cells.
[Human Cell]
Leung, J. K., Tam, T., Wang, J., & Sadar, M. D. (2020). Isolation and characterization of castration-resistant prostate cancer LNCaP95 clones. Human Cell. https://doi.org/10.1007/s13577-020-00435-6 Cite
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piR-001773 and piR-017184 Promote Prostate Cancer Progression by Interacting with PCDH9

The downregulation of PCDH9 in pancreatic cells resulted in an increase in AKT phosphorylation and activity. PCDH9 was posttranscriptionally regulated by P-element-induced wimpy-interacting (piR)-001773 and piR-017184.
[Cellular Signalling]
Zhang, L., Meng, X., Li, D., & Han, X. (2020). piR-001773 and piR-017184 promote prostate cancer progression by interacting with PCDH9. Cellular Signalling, 109780. https://doi.org/10.1016/j.cellsig.2020.109780 Cite
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