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prostate cells

ISL1 Promotes Enzalutamide Resistance in Castration-Resistant Prostate Cancer (CRPC) through Epithelial to Mesenchymal Transition (EMT)

[Scientific Reports] The authors revealed the important role of insulin gene enhancer-binding protein 1 (ISL1) in androgen receptor (AR)-dependent prostate cancer cell growth; ISL1 knockdown reduced the AR activity and cell growth.

Anti-Metastatic Effect of GV1001 on Prostate Cancer Cells; Roles of GnRHR-Mediated Gαs-cAMP Pathway and AR-YAP1 Axis

[Cell & Bioscience] The authors revealed the potential mechanisms of which GV1001-stimulated Gαs-cAMP signaling pathway reduced the migration and metastasis of prostate cancer cells.

Targeting DNMTs to Overcome Enzalutamide Resistance in Prostate Cancer

[Molecular Cancer therapeutics] Scientists suggested that DNA methylation pathway is deregulated after enzalutamide resistance onset and that targeting DNA methyltransferases restored the sensitivity to enzalutamide in prostate cancer cells.

The Influence of Differently Functionalized Nanodiamonds on Proliferation, Apoptosis and EMT/MET Phenomena in 2D and 3D Tumor Cell Cultures

[Journal of Materials Chemistry B] The authors observed that prostate cancer cells and breast cancer cells cultured with nanodiamonds showed morphological changes and altered gene and protein expression.

Epicatechin Gallate Prevents the De Novo Synthesis of Fatty Acid and the Migration of Prostate Cancer Cells

[Acta Biochimica et Biophysica Sinica] Researchers evaluated the potential role of epicatechin gallate in prostate cancer cells and found that epicatechin gallate downregulated the expression of acetyl-CoA carboxylase, ATP citrate lyase, and fatty acid synthase in prostate cancer cells.

Loss of Long Non-Coding RNA NXTAR in Prostate Cancer Augments Androgen Receptor Expression and Enzalutamide Resistance

[Cancer Research] Investigators identified a long non-coding RNA, NXTAR, that was located convergent with the androgen receptor gene and was repressed in human prostate tumors and cell lines.

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