prostate cells

[PLOS One] Investigators combined FX-9 with the currently approved therapeutic agents doxorubicin, carboplatin, the demethylating substance azacitidine as well as further potentially antitumorigenic agents such as dichloroacetic acid in order to evaluate the respective synergistic potential.

[Journal of Extracellular Vesicles] The authors reported that plasma-derived circulating vesicles consisting of CD9 and double-positive for CD9 and Prostate Specific Membrane Antigen were increased in patients with advanced metastatic prostate cancer.

[Aging] In primary and metastatic prostate cancer tissues, circSMARCA5 was significantly downregulated compared with normal controls. Functionally, circSMARCA5 exhibited a suppressive effect on prostate cancer cells' metastasis and growth.

[Journal of Pathology] In prostate cancer cell lines, transgenic mouse models and human prostate tumor cohorts, scientists confirmed that YAP1 RNA and YAP1 protein expression were silenced in neuroendocrine prostate cancer.

[Cell Cycle] The co-expression network of HN1 from the TCGA PRAD dataset indicated the putative role of HN1 in centrosome-related processes in the context of prostate cancer. HN1 expression was low in normal RWPE-1 cells as compared to cancerous androgen-responsive LNCaP and androgen insensitive PC-3 cells.

[eLife] The authors identified 6-phosphogluoconate dehydrogenase as an androgen-regulated gene that was upregulated in prostate cancer.