Investigators aimed to identify a death-associated factor 6 (DAXX)-inducing agent to inhibit tumor initiating cells and prevent proliferation of the tumor.
[npj Breast Cancer]
Researchers demonstrated efficient brain-targeted delivery of apolipoprotein E 2 (ApoE2) encoding plasmid DNA using glucose transporter-1 targeted liposomes.
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The authors leveraged bioinformatics binding prediction tools for human leukocyte antigen (HLA)-I and HLA-II alleles that were developed using mass spectrometry-based profiling of individual HLA-I and HLA-II alleles to predict peptide binding to diverse allele sets.
Scientists investigated a direct role of Yap in constitutive androstane receptor (CAR)‐driven hepatomegaly and hepatocyte proliferation using hepatocyte‐specific Yap‐KO mice. AAV8‐TBG‐CRE vector was injected to Yap‐floxed mice for achieving hepatocyte‐specific Yap deletion followed by TCPOBOP‐treatment.
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Bhushan, B., Molina, L., Koral, K., Stoops, J. W., Mars, W. M., Banerjee, S., Orr, A., Paranjpe, S., Monga, S. P., Locker, J., & Michalopoulos, G. K. (n.d.). Yap is crucial for CAR-driven hepatocyte proliferation, but not for induction of drug metabolism genes in mice. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31521 Cite
Researchers investigated whether sulforaphane could enhance the chemotherapeutic effects of cisplatin and 5-fluorouracil against head and neck squamous cell carcinomas–cancer stem cells, and its mechanisms of action.
[British Journal of Cancer]
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The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.
[Molecular and Cellular Biochemistry]
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MIR503HG negatively regulated its target miR-107. MiR-107 overexpression reversed the anti-tumor effects of MIR503HG overexpression on colon cancer cells. Par4 was a target of miR-107, which was positively regulated by MIR503HG. The promoting effects of MIR503HG silencing on colon cancer cells were eliminated by Par4 overexpression.
[Experimental Cell Research]
Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Researchers examined 19 COVID-19 exposed placentas for histopathologic findings, and for expression of ACE2, and TMPRSS2 by immunohistochemistry.
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Hecht, J. L., Quade, B., Deshpande, V., Mino-Kenudson, M., Ting, D. T., Desai, N., Dygulska, B., Heyman, T., Salafia, C., Shen, D., Bates, S. V., & Roberts, D. J. (2020). SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. Modern Pathology, 1–12. https://doi.org/10.1038/s41379-020-0639-4 Cite
Researchers confirmed autophagy induction by withaferin A (WA) treatment by transmission electron microscopy using three prostate cancer cell lines. Fourteen common genes altered by 8‐ and 16‐hour exposure to WA were identified from human autophagy PCR array and these results were consistent with the RNA‐seq data.
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Researchers showed for the first time that LCN2 mRNA and protein expression were strongly inducible by TNF-α in the highly metastatic human PCa cell line PC-3.
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Investigators propose a plastic differentiation strategy for irreversible differentiation of cancer stem cells, and salinomycin and its newly constructed functional liposomes were used to implement this strategy.
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