Tag Archives: protein expression

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Mesenchymal Stromal (Stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injury

The authors showed that treatment with MSCs decreased expression of host-derived miR-193b-5p and increased expression of its target gene, the tight junctional protein occludin, in lungs from septic mice.

[European Respiratory Journal]

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Isorhapontigenin Ameliorates Cerebral Ischemia/Reperfusion Injury via Modulating Kinase Cε/Nrf2/HO-1 Signaling Pathway

Focal cerebral ischemia-reperfusion injury model and primary cortical neurons were established an oxygen-glucose deprivation injury model. Neuronal cell viability was determined by MTT assay. Western blot analysis was determined for protein expression.

[Brain and Behavior]

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Tissue Microarray Profiling and Integrative Proteomics Indicate the Modulatory Potential of Maytenus royleanus in Inhibition of Overexpressed TPD52 in Prostate Cancers

Scientists explored the mechanism of action of Maytenus royleanus (MEM) in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of various signaling pathways and effected genes to define the mechanism of MEM action in Pca.

[Scientific Reports]

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Heparanase: A Potential Marker of Worse Prognosis in Estrogen Receptor-Positive Breast Cancer

Scientists showed that heparanase promoted tumor progression and increased cell viability via epithelial–mesenchymal transition, stemness, and anti-apoptosis pathways in luminal breast cancer.

[npj Breast Cancer]

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The Heavy Chain of 4F2 Antigen Promote Prostate Cancer Progression via SKP-2

Treatment of C4-2 cells with the 4F2 cell-surface antigen heavy chain was found to suppress cellular growth, migratory and invasive abilities, with this effect occurring through the cell cycle, with a significant decrease in S phase and a significant increase in G0/G1 phase, suggesting cell cycle arrest.

[Scientific Reports]

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A New Role of GRP75-USP1-SIX1 Protein Complex in Driving Prostate Cancer Progression and Castration Resistance

Scientists showed that the molecular chaperone GRP75 is a key player in prostate cancer cells by maintaining the protein stability of SIX1, a transcription factor for embryonic development.

[Oncogene]

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WNT5A Inhibition Alters the Malignant Peripheral Nerve Sheath Tumor Microenvironment and Enhances Tumor Growth

The authors compared gene expression of growth factors in normal human nerves to malignant peripheral nerve sheath tumors (MPNST) and normal human Schwann cells to MPNST cell lines.

[Oncogene]

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Glucose Treatment of Human Pancreatic β-Cells Enhances Translation of mRNAs Involved in Energetics and Insulin Secretion

Reserachers described and validated the use of the SUnSET approach to demonstrate through FACS and Western Blot that glucose increases protein translation in the human cell line EndoC-βH2

[Journal of Biological Chemistry]

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Construction of Enzalutamide-Resistant Cell Model of Prostate Cancer and Preliminary Screening of Potential Drug-Resistant Genes

To develop an enzalutamide-resistant cell model for molecular mechanism investigation of enzalutamide-resistance, researchers continuously treated C4-2B cells with multiplied concentrations of enzalutamide.

[Experimental Biology and Medicine]

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Interleukin-1β-Induced Matrix Metalloproteinase-3 via ERK1/2 Pathway to Promote Mesenchymal Stem Cell Migration

Scientists proposed that IL-1β influences human umbilical cord Wharton’s jelly derived mesenchymal stem cells migration involving matrix metalloproteinase-3.

[PLOS ONE]