The authors analyzed the influence of the in vitro environment on the induction of porcine iPSCs differentiation into primordial germ cell-like cells, providing a suitable in vitro model for use in translational studies and to help answer numerous remaining questions about germ cells.
[Stem Cell Reviews and Reports]
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The authors showed that treatment with MSCs decreased expression of host-derived miR-193b-5p and increased expression of its target gene, the tight junctional protein occludin, in lungs from septic mice.
[European Respiratory Journal]
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Focal cerebral ischemia-reperfusion injury model and primary cortical neurons were established an oxygen-glucose deprivation injury model. Neuronal cell viability was determined by MTT assay. Western blot analysis was determined for protein expression.
[Brain and Behavior]
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Scientists explored the mechanism of action of Maytenus royleanus (MEM) in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of various signaling pathways and effected genes to define the mechanism of MEM action in Pca.
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Scientists showed that heparanase promoted tumor progression and increased cell viability via epithelial–mesenchymal transition, stemness, and anti-apoptosis pathways in luminal breast cancer.
[npj Breast Cancer]
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Treatment of C4-2 cells with the 4F2 cell-surface antigen heavy chain was found to suppress cellular growth, migratory and invasive abilities, with this effect occurring through the cell cycle, with a significant decrease in S phase and a significant increase in G0/G1 phase, suggesting cell cycle arrest.
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Scientists showed that the molecular chaperone GRP75 is a key player in prostate cancer cells by maintaining the protein stability of SIX1, a transcription factor for embryonic development.
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The authors compared gene expression of growth factors in normal human nerves to malignant peripheral nerve sheath tumors (MPNST) and normal human Schwann cells to MPNST cell lines.
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Reserachers described and validated the use of the SUnSET approach to demonstrate through FACS and Western Blot that glucose increases protein translation in the human cell line EndoC-βH2
[Journal of Biological Chemistry]
To develop an enzalutamide-resistant cell model for molecular mechanism investigation of enzalutamide-resistance, researchers continuously treated C4-2B cells with multiplied concentrations of enzalutamide.
[Experimental Biology and Medicine]
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Scientists proposed that IL-1β influences human umbilical cord Wharton’s jelly derived mesenchymal stem cells migration involving matrix metalloproteinase-3.
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