vTv Therapeutics Announces Positive Results from Mechanistic Study Indicating No Increased Risk of Ketoacidosis with TTP399 during Acute Insulin Withdrawal in Patients with Type 1 Diabetes

vTv Therapeutics, Inc. a clinical-stage biopharmaceutical company focused on the development of orally administered treatments for type 1 diabetes and psoriasis, announced positive results of a mechanistic study of TTP399 in patients with type 1 diabetes.
[vTv Therapeutics, Inc.]
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Biomaterial-Enabled Induction of Pancreatic-Specific Regulatory T Cells through Distinct Signal Transduction Pathways

Scientists used poly (lactic-co-glycolide) to co-encapsulate type 1 diabetes-relevant antigen and 3 distinct TREG-inducing molecules – rapamycin, all-trans retinoic acid, and butyrate – that targeted the mechanistic target of Rapa, the retinoid pathway, and histone deacetylase inhibition, respectively.
[Drug Delivery and Translational Research]
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Detecting Insulitis in Type 1 Diabetes with Ultrasound Phase-Change Contrast Agents

Researchers presented ultrasound imaging of nanodroplet (ND) contrast-agent accumulation within the islet. ND accumulation is dependent on immune infiltration; therefore, it tracked presymptomatic type I diabetes development and progression to diabetes
[Proceedings of the National Academy of Sciences of the United States of America]
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Precigen ActoBio Announces Additional Positive Interim Data from Phase 1b/2a Study of AG019 ActoBiotics™, a Novel Therapy Designed to Address the Underlying Cause of Type 1 Diabetes

Precigen ActoBio, announced additional positive interim data from the ongoing Phase 1b/2a clinical study investigating AG019 ActoBiotics for the treatment of recent-onset type 1 diabetes.
[Precigen ActoBio]
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Microvessels Support Engraftment and Functionality of Human Islets and hESC-Derived Pancreatic Progenitors in Diabetes Models

Scientists enhanced subcutaneous engraftment by employing a unique vascularization strategy based on ready-made microvessels isolated from the adipose tissue.
[Cell Stem Cell]
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Puerarin Inhibits the PERK-eIF2α-ATF4-CHOP Pathway through Inactivating JAK2/STAT3 Signal in Pancreatic Beta-Cells

Researchers investigated the role of puerarin in endoplasmic reticulum stress-associated apoptosis and explore its underlying mechanism in the mouse insulinoma cell line.
[American Journal of Chinese Medicine]
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T Cell Receptor Recognition of Hybrid Insulin Peptides Bound to HLA-DQ8

HLA-DQ8-HIP tetramer+ T cells from the peripheral blood of a T1D patient are characterized by repeated TRBV5 usage, which matched the TCR bias of CD4+ T cells reactive to the HIP peptide isolated from the pancreatic islets of a patient with T1D.
[Nature Communications]
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Tet2 Controls the Responses of β Cells to Inflammation in Autoimmune Diabetes

Researchers showed that Tet2 regulated pathologic interactions between β cells and immune cells and controlled damaging inflammatory pathways.
[Nature Communications]
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Engineering Islets from Stem Cells for Advanced Therapies of Diabetes

Scientists discuss the state of the art of stem cell differentiation and islet engineering, reflect on current and future challenges in the area and highlight the potential for cell replacement therapies, disease modelling and drug development using these cells.
[Nature Reviews Drug Discovery]
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The Parasite-Derived Peptide FhHDM-1 Activates the PI3K/Akt Pathway to Prevent Cytokine-Induced Apoptosis of β-Cells

Scientists showed that proteomic analyses of pancreas tissue from non-obese diabetic (NOD) mice suggested that FhHDM-1 activated the PI3K/Akt signalling pathway, which was associated with β-cell metabolism, survival and proliferation.
[Journal of Molecular Medicine]
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Sonoma Biotherapeutics Raises $265M to Advance Therapies for Autoimmune, Inflammatory Diseases

Sonoma Biotherapeutics has raised $265 million in new funding which will be used to advance its programs aiming to treat autoimmune and inflammatory conditions such as rheumatoid arthritis, type 1 diabetes, and IBD.
[GeekWire]
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