CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma

Scientists identified CEACAM7 as a potential therapeutic target in PDAC and described the development of CEACAM7-targeted CAR T cells with efficacy against PDAC.
[Clinical Cancer Research]
Raj, D., Nikolaidi, M., Garces, I., Lorizio, D., Castro, N. M., Caiafa, S. G., Moore, K., Brown, N. F., Kocher, H. M., Duan, X., Nelson, B. H., Lemoine, N. R., & Marshall, J. F. (2021). CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-19-2163 Cite
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Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes

Researchers suggested that microdose lithium conferred a protective effect on islet β-cells via targeting the GSK3β-regulated Nrf2 antioxidant response and thereby ameliorated type 1 diabetes mellitus and its related kidney impairment.
[Antioxidants]
Zhang, J., Anshul, F., Malhotra, D. K., Jaume, J., Dworkin, L. D., & Gong, R. (2021). Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes. Antioxidants, 10(1), 138. https://doi.org/10.3390/antiox10010138 Cite
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SHANK2 Mutations Impair Apoptosis, Proliferation and Neurite Outgrowth during Early Neuronal Differentiation in SH-SY5Y Cells

Using CRISPR/Cas9 genome editing, scientists obtaineded SH-SY5Y cell lines with frameshift mutations on one or both SHANK2 alleles. They investigated the effects of the different SHANK2 mutations on cell morphology, cell proliferation and differentiation potential during early neuronal differentiation.
[Scientific Reports]
Unsicker, C., Cristian, F.-B., von Hahn, M., Eckstein, V., Rappold, G. A., & Berkel, S. (2021). SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells. Scientific Reports, 11(1), 2128. https://doi.org/10.1038/s41598-021-81241-4 Cite
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Smoothened-Activating Lipids Drive Resistance to CDK4/6 Inhibition in Hedgehog-Associated Medulloblastoma Cells and Preclinical Models

Scientists identified resistance mechanisms to CDK6 inhibition in Hedgehog (HH)-associated medulloblastoma by performing orthogonal CRISPR and CRISPR interference screens in medulloblastoma cells treated with a CDK4/6 inhibitor, and RNA-sequencing of a mouse model of HH-associated medulloblastoma with genetic deletion of Cdk6.
[Journal of Clinical Investigation]
JCI - Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models. (n.d.). Retrieved January 22, 2021, from https://www.jci.org/articles/view/141171 Cite
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Prpf31 Is Essential for the Survival and Differentiation of Retinal Progenitor Cells by Modulating Alternative Splicing

The authors showed that the differentiation and viability of retinal progenitor cells were severely perturbed in prpf31 knockout zebrafish when compared with other tissues at an early embryonic stage.
[Nucleic Acids Research]
Li, J., Liu, F., Lv, Y., Sun, K., Zhao, Y., Reilly, J., Zhang, Y., Tu, J., Yu, S., Liu, X., Qin, Y., Huang, Y., Gao, P., Jia, D., Chen, X., Han, Y., Shu, X., Luo, D., Tang, Z., & Liu, M. (2021). Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Nucleic Acids Research, gkab003. https://doi.org/10.1093/nar/gkab003 Cite
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Modulation of Nogo Receptor 1 Expression Orchestrates Myelin-Associated Infiltration of Glioblastoma

Investigators adopted a radiogenomic analysis to screen for functionally relevant genes that orchestrated the process of glioma cell infiltration through myelin and promoted glioblastoma aggressiveness.
[Brain]
Hong, J.-H., Kang, S., Sa, J. K., Park, G., Oh, Y. T., Kim, T. H., Yin, J., Kim, S. S., D’Angelo, F., Koo, H., You, Y., Park, S., Kwon, H. J., Kim, C. I., Ryu, H., Lin, W., Park, E. J., Kim, Y.-J., Park, M.-J., … Park, J. B. (2021). Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma. Brain, awaa408. https://doi.org/10.1093/brain/awaa408 Cite
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Endoplasmic Reticulum Interaction Supports Energy Production and Redox Homeostasis in Mitochondria Released from Astrocytes

Mitochondria can be released by astrocytes as part of a help-me signaling process in stroke. Scientists investigated the molecular mechanisms that underlay mitochondria secretion, redox status, and functional regulation in the extracellular environment.
[Translational Stroke Research]
Park, J.-H., Lo, E. H., & Hayakawa, K. (2021). Endoplasmic Reticulum Interaction Supports Energy Production and Redox Homeostasis in Mitochondria Released from Astrocytes. Translational Stroke Research. https://doi.org/10.1007/s12975-021-00892-7 Cite
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Activation of the Tumor Suppressive Hippo Pathway by Triptonide as a New Strategy to Potently Inhibit Aggressive Melanoma Cell Metastasis

Researchers showed that the small molecule triptonide robustly suppressed melanoma cell tumorigenicity, migration, and invasion.
[Biochemical Pharmacology]
Tan, S., Zhao, Z., Qiao, Y., Zhang, B., Zhang, T., Zhang, M., Qi, J., Wang, X., Meng, M., & Zhou, Q. (2021). Activation of the tumor suppressive Hippo pathway by triptonide as a new strategy to potently inhibit aggressive melanoma cell metastasis. Biochemical Pharmacology, 114423. https://doi.org/10.1016/j.bcp.2021.114423 Cite
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Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase

Human keratinocytes cells were used as an experimental model for studies on the effects of platelet-rich plasma on cell proliferation, migration, collagen biosynthesis, prolidase activity, and its expression and anabolic signaling.
[International Journal of Molecular Sciences]
Misiura, M., Guszczyn, T., Oscilowska, I., Baszanowska, W., Palka, J., & Miltyk, W. (2021). Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase. International Journal of Molecular Sciences, 22(2), 936. https://doi.org/10.3390/ijms22020936 Cite
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NECTIN4: A Novel Therapeutic Target for Melanoma

The authors investigated the role of nectin cell adhesion molecule 4 (NECTIN4) in melanoma and its potency as a therapeutic target using 126 melanoma samples and BRAFi-resistant cells.
[International Journal of Molecular Sciences]
Tanaka, Y., Murata, M., Shen, C.-H., Furue, M., & Ito, T. (2021). NECTIN4: A Novel Therapeutic Target for Melanoma. International Journal of Molecular Sciences, 22(2), 976. https://doi.org/10.3390/ijms22020976 Cite
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Real-Time Lipid Patterns to Classify Viable and Necrotic Liver Tumors

The authors explored whether rapid evaporative ionization mass spectrometry lipid patterns ccould identify human liver tumors and improve the rapid characterization of their underlying metabolic features.
[Laboratory Investigation]
Vaysse, P.-M., Grabsch, H. I., van den Hout, M. F. C. M., Bemelmans, M. H. A., Heeren, R. M. A., Olde Damink, S. W. M., & Porta Siegel, T. (2021). Real-time lipid patterns to classify viable and necrotic liver tumors. Laboratory Investigation, 1–15. https://doi.org/10.1038/s41374-020-00526-w Cite
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