Publication

[Applied Biochemistry And Biotechnology] A bacterial EPS from the marine bacterium Halomonas malpeensis YU-PRIM-29T was used to treat the burn wound in vivo. In vitro biocompatibility of EPS-H29 was studied in human dermal fibroblasts and keratinocytes.

[Communications Biology] Investigators reported that Dab2 conditional knockout mice exhibited a delay in the hair follicle cycle due to perturbed activation of hair follicle stem cells.

[Nature Communications] Using lineage tracing studies along with transcriptomic characterization, scientists demonstrated that treatment of adult mice with a small molecule that inhibits kinase activity of focal adhesion kinase resulted in trans-differentiation of a subset of peri-islet acinar cells into insulin producing β-like cells.

[Diabetes Obesity & Metabolism] Genetic animal models and transgenic immortalized cells were applied to study the effect of adenosine kinase on islet beta-cell proliferation and function.

[Advanced Materials] Black phosphorus nanosheets (BPNSs) interacted directly with α-synuclein (α-syn) fibrils to trigger their disaggregation for Parkinson's disease treatment. BPNSs were found to activate autophagy to maintain α-syn homeostasis, improve mitochondrial dysfunction, reduce reactive oxygen species levels, and rescue neuronal death and synaptic loss in PC12 cells.

[Brain] Correlative light and electron microscopy were employed to investigate alpha-synuclein pathology in the substantia nigra and putamen of post-mortem multiple system atrophy brain donors.