SCAMP3 Is a Mutant EGFR Phosphorylation Target and a Tumor Suppressor in Lung Adenocarcinoma

Scientist used quantitative mass-spectrometry-based phosphoproteomics to identify secretory carrier membrane proteins (SCAMP3) as a target of mutant epidermal growth factor receptor in lung adenocarcinoma and further investigated the role of SCAMP3 in the regulation of lung tumorigenesis.
[Oncogene]
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HIF-1α Promoted Vasculogenic Mimicry Formation in Lung Adenocarcinoma through NRP1 Upregulation in the Hypoxic Tumor Microenvironment

Researchers explored the role of the HIF-1α/NRP1 axis in mediating lung adenocarcinoma metastasis and vasculogenic mimicry (VM) formation.
[Cell Death & Disease]
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Distinct Uptake, Amplification, and Release of SARS-CoV-2 by M1 and M2 Alveolar Macrophages

Investigators showed that classically activated M1 alveolar macrophages (AMs) facilitated viral spread; however, alternatively activated M2 AMs limited the spread.
[Cell Discovery]
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Therapeutic Targeting of ATR Yields Durable Regressions in Small Cell Lung Cancers with High Replication Stress

Using chemical genetic screens, scientists identified inhibition of ataxia telangiectasia and rad3 related (ATR), the primary activator of the replication stress response, and topoisomerase I (TOP1), nuclear enzyme that suppressed genomic instability, as synergistically cytotoxic in small cell lung cancer (SCLC).
[Cancer Cell]
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Vitamin D and Lumisterol Derivatives Can Act on Liver X Receptors (LXRs)

Scientists investigated the interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs)
[Scientific Reports]
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Dnmt3a Deficiency in the Skin Causes Focal, Canonical DNA Hypomethylation and a Cellular Proliferation Phenotype

Researchers detected a focal, canonical hypomethylation phenotype that revealed considerable overlap with hypomethylated regions found in Dnmt3a-deficient mouse skin.
[Proceedings of the National Academy of Sciences of the United States of America]
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Bmal1 Inhibits Phenotypic Transformation of Hepatic Stellate Cells in Liver Fibrosis via IDH1/α-KG-Mediated Glycolysis

Scientists showed that glycolysis was significantly enhanced, while the expression of brain and muscle arnt-like protein-1 (Bmal1) was downregulated in fibrotic liver tissues of mice, primary Hepatic stellate cells (HSCs), and transforming growth factor-β1 (TGF-β1)-induced LX2 cells.
[Acta Pharmaceutica Sinica B]
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2D Vanadium Carbide MXenzyme to Alleviate ROS-Mediated Inflammatory and Neurodegenerative Diseases

Based on the enzyme-mimicking properties, the constructed 2D vanadium carbide MXene nanoenzyme (MXenzyme) not only possessed high biocompatibility but also exhibited robust in vitro cytoprotection against oxidative stress.
[Nature Communications]
Feng, W., Han, X., Hu, H., Chang, M., Ding, L., Xiang, H., Chen, Y., & Li, Y. (2021). 2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases. Nature Communications, 12(1), 2203. https://doi.org/10.1038/s41467-021-22278-x Cite
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Cromolyn Inhibits the Secretion of Inflammatory Cytokines by Human Microglia (HMC3)

To better understand the mechanistic effect cromolyn has in slowing down or halting the neuroinflammatory response associated with Alzheimer’s Disease progression, the authors tested the effect of cromolyn to dampen the inflammatory response in the human HMC3 microglia cell line.
[Scientific Reports]
Wang, Y.-J., Monteagudo, A., Downey, M. A., Ashton-Rickardt, P. G., & Elmaleh, D. R. (2021). Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3). Scientific Reports, 11(1), 8054. https://doi.org/10.1038/s41598-021-85702-8 Cite
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The Connectome of Neural Crest Enhancers Reveals Regulatory Features of Signaling Systems

To examine the role of long-range DNA interactions in early development, researchers generated a high-resolution contact map of active enhancers in avian neural crest cells.
[Developmental Cell]
Azambuja, A. P., & Simoes-Costa, M. (2021). The connectome of neural crest enhancers reveals regulatory features of signaling systems. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2021.03.024 Cite
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Brd4-Bound Enhancers Drive Cell-Intrinsic Sex Differences in Glioblastoma

Researchers discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large Brd4-bound enhancer usage, and Brd4 localization to Myc and p53 genomic binding sites. These sex-biased gene expression patterns were also evident in human glioblastoma stem cells.
[Proceedings of the National Academy of Sciences of the United States of America]
Kfoury, N., Qi, Z., Prager, B. C., Wilkinson, M. N., Broestl, L., Berrett, K. C., Moudgil, A., Sankararaman, S., Chen, X., Gertz, J., Rich, J. N., Mitra, R. D., & Rubin, J. B. (2021). Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma. Proceedings of the National Academy of Sciences, 118(16). https://doi.org/10.1073/pnas.2017148118 Cite
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