Using phage display, researchers isolated single-chain variable fragments specific for each mutant peptide-HLA complexes.
[Science Immunology]
Douglass, J., Hsiue, E. H.-C., Mog, B. J., Hwang, M. S., DiNapoli, S. R., Pearlman, A. H., Miller, M. S., Wright, K. M., Azurmendi, P. A., Wang, Q., Paul, S., Schaefer, A., Skora, A. D., Molin, M. D., Konig, M. F., Liu, Q., Watson, E., Li, Y., Murphy, M. B., … Zhou, S. (2021). Bispecific antibodies targeting mutant RAS neoantigens. Science Immunology, 6(57). https://doi.org/10.1126/sciimmunol.abd5515 Cite
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