Scientists demonstrated that tissue mechanics, or the stiffness of the wound bed, the ECM, and the stiffness of the cells also partook during wound-induced hair neogenesis; the hair primordia formation was not exclusive to molecular signaling events.
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Investigators performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy.
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To understand how Notch signaling was overactivated to couple tumor metastasis and self-renewal in NSCLC cells, researchers showed that RFC4, directly bound to the Notch1 intracellular domain (NICD1) to competitively abrogate CDK8/FBXW7-mediated degradation of NICD1.
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Stress-driven ribosomal dysfunction enhanced PR domain zinc finger protein 1 (PRDM1) levels in intestinal cancer cells, which contributed to their survival and enhanced cancer cell stemness against cancer treatment.
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The authors established patient-derived renal cell carcinoma spheroids and showed that dipeptidyl peptidase IV (DPP4) expression was associated with stemness-related gene expression.
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Scientists review the roles of the p90 ribosomal S6 kinases in proliferation and motility, cell cycle control and therapy resistance in prostate cancer, highlighting the possible interplay between RSKs and Androgen Receptor in mediating disease progression.
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Using the Chromium 10X platform, scientists sequenced a total of ~ 120,000 cells from fresh and cryopreserved replicates across three primary breast cancers, two primary prostate cancers and a cutaneous melanoma.
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Analysis of CD45RA-depleted haploidentical mixed lymphocytes culture revealed insufficient suppression of alloresponses in the CD4+ compartment and identified CD276 as a marker for alloreactive memory Th1 T cells.
[Bone Marrow Transplantation]
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Hashimoto, H., Kasteleiner, P., Kressin, J., Müller, F., Bühring, H.-J., Handgretinger, R., & Schilbach, K. (2021). Removal of CD276 + cells from haploidentical memory T-cell grafts significantly lowers the risk of GVHD. Bone Marrow Transplantation, 1–19. https://doi.org/10.1038/s41409-021-01307-9 Cite
Researchers engineered red blood cells into artificial antigen-presenting cells presenting a peptide bound to the major histocompatibility complex I, the costimulatory ligand 4-1BBL, and interleukin-12.
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Zhang, X., Luo, M., Dastagir, S. R., Nixon, M., Khamhoung, A., Schmidt, A., Lee, A., Subbiah, N., McLaughlin, D. C., Moore, C. L., Gribble, M., Bayhi, N., Amin, V., Pepi, R., Pawar, S., Lyford, T. J., Soman, V., Mellen, J., Carpenter, C. L., … Chen, T. F. (2021). Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic. Nature Communications, 12(1), 2637. https://doi.org/10.1038/s41467-021-22898-3 Cite
The authors demonstrated that DNMT3A haploinsufficiency impaired the gain of DNA methylation at decommissioned enhancers, while simultaneously and unexpectedly impairing DNA demethylation of newly activated enhancers in mature human myeloid cells.
[Journal of Experimental Medicine]
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Lim, J.-Y., Duttke, S. H., Baker, T. S., Lee, J., Gambino, K. J., Venturini, N. J., Ho, J. S. Y., Zheng, S., Fstkchyan, Y. S., Pillai, V., Fajgenbaum, D. C., Marazzi, I., Benner, C., & Byun, M. (2021). DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells. Journal of Experimental Medicine, 218(e20202733). https://doi.org/10.1084/jem.20202733 Cite
Scientists examined CD4 T cells in donor-matched vaginal, ecto- and endocervical tissues, which differ in mucosal structure and exposure to external environmental stimuli.
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Woodward Davis, A. S., Vick, S. C., Pattacini, L., Voillet, V., Hughes, S. M., Lentz, G. M., Kirby, A. C., Fialkow, M. F., Gottardo, R., Hladik, F., Lund, J. M., & Prlic, M. (2021). The human memory T cell compartment changes across tissues of the female reproductive tract. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-021-00406-6 Cite