Tag Archives: type-publication

The NLRP3 Inflammasome Inhibitor OLT1177 Rescues Cognitive Impairment in a Mouse Model of Alzheimer’s Disease

Scientists analyzed the effect of pharmacological inhibition of the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome using dapansutrile (OLT1177), an oral NLRP3-specific inhibitor that is safe in humans.
[Proceedings of the National Academy of Sciences of the United States of America]
Lonnemann, N., Hosseini, S., Marchetti, C., Skouras, D. B., Stefanoni, D., D’Alessandro, A., Dinarello, C. A., & Korte, M. (2020). The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2009680117 Cite
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The ZNF750–RAC1 Axis as Potential Prognostic Factor for Breast Cancer

Reseachers showed that ZNF750 negatively regulates cell migration and invasion in breast cancer cells; in particular, ZNF750 binds and recruits KDM1A and HDAC1 on the LAMB3 and CTNNAL1 promoters.
[Cell Death Discovery]
Butera, A., Cassandri, M., Rugolo, F., Agostini, M., & Melino, G. (2020). The ZNF750–RAC1 axis as potential prognostic factor for breast cancer. Cell Death Discovery, 6(1), 1–9. https://doi.org/10.1038/s41420-020-00371-2 Cite
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Single Cell RNA Sequencing of Human Microglia Uncovers a Subset Associated with Alzheimer’s Disease

Scientists investigated the population structure of live microglia purified from human cerebral cortex samples obtained at autopsy and during neurosurgical procedures.
[Nature Communications]
Olah, M., Menon, V., Habib, N., Taga, M. F., Ma, Y., Yung, C. J., Cimpean, M., Khairallah, A., Coronas-Samano, G., Sankowski, R., Grün, D., Kroshilina, A. A., Dionne, D., Sarkis, R. A., Cosgrove, G. R., Helgager, J., Golden, J. A., Pennell, P. B., Prinz, M., … De Jager, P. L. (2020). Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease. Nature Communications, 11(1), 6129. https://doi.org/10.1038/s41467-020-19737-2 Cite
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Chronic Neuronal Activation Increases Dynamic Microtubules to Enhance Functional Axon Regeneration after Dorsal Root Crush Injury

Researchers found that chemogenetic activation of adult dorsal root ganglion neurons improves axon growth on an in vitro model of the inhibitory environment after injury.
[Nature Communications]
Wu, D., Jin, Y., Shapiro, T. M., Hinduja, A., Baas, P. W., & Tom, V. J. (2020). Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury. Nature Communications, 11(1), 6131. https://doi.org/10.1038/s41467-020-19914-3 Cite
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Histone H3.3G34-Mutant Interneuron Progenitors Co-Opt PDGFRA for Gliomagenesis

The authors showed that 50% of glycine 34 to arginine/valine (G34R/V) tumors bore activating PDGFRA mutations that displayed strong selection pressure at recurrence. G34R/V tumors arise in GSX2/ DLX-expressing interneuron progenitors, where G34R/V mutations impair neuronal differentiation.
[Cell]
Chen, C. C. L., Deshmukh, S., Jessa, S., Hadjadj, D., Lisi, V., Andrade, A. F., Faury, D., Jawhar, W., Dali, R., Suzuki, H., Pathania, M., A, D., Dubois, F., Woodward, E., Hébert, S., Coutelier, M., Karamchandani, J., Albrecht, S., Brandner, S., … Jabado, N. (2020). Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.11.012 Cite
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The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis

Colorectal cancer (CRC) tumoroids and a mouse model of CRC hepatic metastasis were used to test approaches to modify bone morphogenetic protein signaling and treat CRC.
[Gastroenterology]
Kobayashi, H., Gieniec, K. A., Wright, J. A., Wang, T., Asai, N., Mizutani, Y., Ida, T., Ando, R., Suzuki, N., Lannagan, T. R., Ng, J. Q., Hara, A., Shiraki, Y., Mii, S., Ichinose, M., Vrbanac, L., Lawrence, M. J., Sammour, T., Uehara, K., … Woods, S. L. (2020). The balance of stromal BMP signaling mediated by GREM1 and ISLR drives colorectal carcinogenesis. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.11.011 Cite
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The Hexosamine Biosynthesis Pathway Is a Targetable Liability in KRAS/LKB1 Mutant Lung Cancer

Glutamine-fructose-6-phosphate transaminase [isomerizing] 2 inhibition selectively reduced KRAS/LKB1 co-mutant tumour cell growth in culture, xenografts and genetically modified mice.
[Nature Metabolism]
Kim, J., Lee, H. M., Cai, F., Ko, B., Yang, C., Lieu, E. L., Muhammad, N., Rhyne, S., Li, K., Haloul, M., Gu, W., Faubert, B., Kaushik, A. K., Cai, L., Kasiri, S., Marriam, U., Nham, K., Girard, L., Wang, H., … DeBerardinis, R. J. (2020). The hexosamine biosynthesis pathway is a targetable liability in KRAS / LKB1 mutant lung cancer. Nature Metabolism, 1–12. https://doi.org/10.1038/s42255-020-00316-0 Cite
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CCL7 Recruits cDC1 to Promote Antitumor Immunity and Facilitate Checkpoint Immunotherapy to Non-Small Cell Lung Cancer

Researchers demonstrated that CCL7 facilitates anti-PD-1 therapy for the KrasLSL−G12D/+Tp53fl/fl and the KrasLSL−G12D/+Lkb1fl/fl non-small cell lung cancer mouse models by recruiting conventional DC 1 (cDC1) into the tumor microenvironment to promote T cell expansion.
[Nature Communications]
Zhang, M., Yang, W., Wang, P., Deng, Y., Dong, Y.-T., Liu, F.-F., Huang, R., Zhang, P., Duan, Y.-Q., Liu, X.-D., Lin, D., Chu, Q., & Zhong, B. (2020). CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nature Communications, 11(1), 6119. https://doi.org/10.1038/s41467-020-19973-6 Cite
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BETs Inhibition Attenuates Oxidative Stress and Preserves Muscle Integrity in Duchenne Muscular Dystrophy

Scientists showed that protein levels of the Bromodomain and extra-terminal domain (BET) protein BRD4 were significantly increased in the muscle of the mouse model of Duchenne muscular dystrophy, the mdx mouse, and that pharmacological inhibition of the BET proteins had a beneficial outcome, tempering oxidative stress and muscle damage.
[Nature Communications]
Segatto, M., Szokoll, R., Fittipaldi, R., Bottino, C., Nevi, L., Mamchaoui, K., Filippakopoulos, P., & Caretti, G. (2020). BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy. Nature Communications, 11(1), 6108. https://doi.org/10.1038/s41467-020-19839-x Cite
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YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells

The authors demonstrated that the Hippo pathway effectors YAP and TAZ play a critical role in maintaining the differentiated contractile phenotype of vascular smooth muscle cells.
[iScience]
Wang, L., Chennupati, R., Jin, Y.-J., Li, R., Wang, S., Günther, S., & Offermanns, S. (2020). YAP/TAZ are required to suppress osteogenic differentiation of vascular smooth muscle cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101860 Cite
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CARM1 Regulates AMPK Signaling in Skeletal Muscle

The authors observed altered interactions between coactivator-associated arginine methyltransferase 1 (CARM1) and AMP-activated protein kinase (AMPK) and its network, including forkhead box protein O1, during muscle disuse.
[iScience]
Stouth, D. W., vanLieshout, T. L., Ng, S. Y., Webb, E. K., Manta, A., Moll, Z., & Ljubicic, V. (2020). CARM1 Regulates AMPK Signaling in Skeletal Muscle. IScience, 23(11), 101755. https://doi.org/10.1016/j.isci.2020.101755 Cite
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