Bispecific Antibodies Targeting Mutant Ras Neoantigens

Using phage display, researchers isolated single-chain variable fragments specific for each mutant peptide-HLA complexes.
[Science Immunology]
Douglass, J., Hsiue, E. H.-C., Mog, B. J., Hwang, M. S., DiNapoli, S. R., Pearlman, A. H., Miller, M. S., Wright, K. M., Azurmendi, P. A., Wang, Q., Paul, S., Schaefer, A., Skora, A. D., Molin, M. D., Konig, M. F., Liu, Q., Watson, E., Li, Y., Murphy, M. B., … Zhou, S. (2021). Bispecific antibodies targeting mutant RAS neoantigens. Science Immunology, 6(57). https://doi.org/10.1126/sciimmunol.abd5515 Cite
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Circulating CD103+ γδ and CD8+ T Cells Are Clonally Shared with Tissue-Resident Intraepithelial Lymphocytes in Celiac Disease

Scientists obtained γδ and αβ TCR sequences of >2500 single cells from blood and gut of 5 patients, before and during challenge. We observed extensive sharing between blood and gut γδ and CD8+ αβ T-cell clonotypes even prior to gluten challenge.
[Mucosal Immunology]
Risnes, L. F., Eggesbø, L. M., Zühlke, S., Dahal-Koirala, S., Neumann, R. S., Lundin, K. E. A., Christophersen, A., & Sollid, L. M. (2021). Circulating CD103 + γδ and CD8 + T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease. Mucosal Immunology, 1–10. https://doi.org/10.1038/s41385-021-00385-8 Cite
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Autologous Transplant Therapy Alleviates Motor and Depressive Behaviors in Parkinsonian Monkeys

Scientists showed that over a two-year period without immunosuppression, Parkinson’s disease monkeys receiving autologous, but not allogenic, transplantation exhibited recovery from motor and depressive signs.
[Nature Medicine]
Tao, Y., Vermilyea, S. C., Zammit, M., Lu, J., Olsen, M., Metzger, J. M., Yao, L., Chen, Y., Phillips, S., Holden, J. E., Bondarenko, V., Block, W. F., Barnhart, T. E., Schultz-Darken, N., Brunner, K., Simmons, H., Christian, B. T., Emborg, M. E., & Zhang, S.-C. (2021). Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. Nature Medicine, 1–8. https://doi.org/10.1038/s41591-021-01257-1 Cite
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A Single-Chain Antibody Generation System Yielding Car-T Cells with Superior Antitumor Function

Researchers established a single-chain antibody (scFv) generation system in which scFv library-expressing CAR-T cells can be screened appropriately based on their antitumor functions.
[Communications Biology]
Ochi, T., Maruta, M., Tanimoto, K., Kondo, F., Yamamoto, T., Kurata, M., Fujiwara, H., Masumoto, J., Takenaka, K., & Yasukawa, M. (2021). A single-chain antibody generation system yielding CAR-T cells with superior antitumor function. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-01791-1 Cite
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Bet Proteolysis Targeted Chimera-Based Therapy of Novel Models of Richter Transformation-Diffuse Large B-Cell Lymphoma

Co-treatment with BET inhibitor or BET-PROTAC and ibrutinib or venetoclax exerted synergistic in vitro lethality in the diffuse large B cell lymphoma cells.
[Leukemia]
Fiskus, W., Mill, C. P., Perera, D., Birdwell, C., Deng, Q., Yang, H., Lara, B. H., Jain, N., Burger, J., Ferrajoli, A., Davis, J. A., Saenz, D. T., Jin, W., Coarfa, C., Crews, C. M., Green, M. R., Khoury, J. D., & Bhalla, K. N. (2021). BET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma. Leukemia, 1–14. https://doi.org/10.1038/s41375-021-01181-w Cite
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FOXO3-Induced lncRNA LOC554202 Contributes to Hepatocellular Carcinoma Progression via the miR-485-5p/Bsg Axis

Scientists reported that LOC554202 expression was distinctly upregulated in HCC specimens and cell lines.
[Cancer Gene Therapy]
Yang, L., Deng, W., Zhao, B., Xu, Y., Wang, X., Fang, Y., & Xiao, H. (2021). FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis. Cancer Gene Therapy, 1–15. https://doi.org/10.1038/s41417-021-00312-w Cite
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LL-37-Mediated Activation of Host Receptors Is Critical for Defense against Group A Streptococcal Infection

Researchers showed that Group A Streptococcus extracellular protease ScpC N-terminally cleaves LL-37 into two fragments of 8 and 29 amino acids, preserving its bactericidal activity.
[Cell Reports]
Biswas, D., Ambalavanan, P., Ravins, M., Anand, A., Sharma, A., Lim, K. X. Z., Tan, R. Y. M., Lim, H. Y., Sol, A., Bachrach, G., Angeli, V., & Hanski, E. (2021). LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection. Cell Reports, 34(9). https://doi.org/10.1016/j.celrep.2021.108766 Cite
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Deep Immune Profiling of Mis-C Demonstrates Marked but Transient Immune Activation Compared to Adult and Pediatric COVID-19

Investigators analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients and patients with Multisystem Inflammatory Syndrome in Children.
[Science Immunology]
Vella, L. A., Giles, J. R., Baxter, A. E., Oldridge, D. A., Diorio, C., Kuri-Cervantes, L., Alanio, C., Pampena, M. B., Wu, J. E., Chen, Z., Huang, Y. J., Anderson, E. M., Gouma, S., McNerney, K. O., Chase, J., Burudpakdee, C., Lee, J. H., Apostolidis, S. A., Huang, A. C., … Wherry, E. J. (2021). Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. Science Immunology, 6(57). https://doi.org/10.1126/sciimmunol.abf7570 Cite
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Next Generation Methodology for Updating Ha Vaccines against Emerging Human Seasonal Influenza A(H3N2) Viruses

Building upon the COBRA technology, nine next-generation H3N2 influenza hemagglutinin (HA) vaccines were designed using a next generation algorithm and design methodology.
[Scientific Reports]
Allen, J. D., & Ross, T. M. (2021). Next generation methodology for updating HA vaccines against emerging human seasonal influenza A(H3N2) viruses. Scientific Reports, 11(1), 4554. https://doi.org/10.1038/s41598-020-79590-7 Cite
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Immunogenicity and Protective Efficacy of Inactivated SARS-CoV-2 Vaccine Candidate, BBV152 in Rhesus Macaques

Scientists developed and assessed the protective efficacy and immunogenicity of an inactivated SARS-CoV-2 vaccine in rhesus macaques.
[Nature Communications]
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The Prevalence of Antibodies to SARS-CoV-2 among Blood Donors in China

Scientists investigated the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China.
[Nature Communications]
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