Black Phosphorus Nanosheets Protect Neurons by Degrading Aggregative α-Syn and Clearing ROS in Parkinson’s Disease

Black phosphorus nanosheets (BPNSs) interacted directly with α-synuclein (α-syn) fibrils to trigger their disaggregation for Parkinson’s disease treatment. BPNSs were found to activate autophagy to maintain α-syn homeostasis, improve mitochondrial dysfunction, reduce reactive oxygen species levels, and rescue neuronal death and synaptic loss in PC12 cells.