Black Phosphorus Nanosheets Protect Neurons by Degrading Aggregative α-Syn and Clearing ROS in Parkinson’s Disease

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Black phosphorus nanosheets (BPNSs) interacted directly with α-synuclein (α-syn) fibrils to trigger their disaggregation for Parkinson’s disease treatment. BPNSs were found to activate autophagy to maintain α-syn homeostasis, improve mitochondrial dysfunction, reduce reactive oxygen species levels, and rescue neuronal death and synaptic loss in PC12 cells.
[Advanced Materials]
Abstract