Publication

[Aging And Disease] Investigators observed the induction of neuronal plasticity and a reduction of neuroinflammation after G9a inhibitor treatment, and these neuroprotective effects were reverted by the pharmacological inhibition of GMFB in mice and cell cultures.

[CNS Neuroscience & Therapeutics] Glioblastoma stem cells (GSCs)-derived exosomal miR-6733-5p induced macrophage M2 polarization of tumor-associated macrophages by positively targeting IGF2BP3 to activate the AKT signaling pathway, which further facilitated the self-renewal and stemness of GSCs.

[Annals Of Clinical And Translational Neurology] Investigators established the Rett syndrome (RTT) brain organoid model derived from MeCP2-truncated induced pluripotent stem cells which were genetically engineered by CRISPR/Cas9 technology. By immunofluorescence imaging, they studied the development of neural progenitor cell pool and its fate specification into glutamatergic neurons or astrocytes in RTT organoids.

[Journal Of Neurotrauma] Scientists characterized the downstream cytokine response of human induced pluripotent stem cell-derived microglia when stimulated with five separate cytokines identified following human traumatic brain injury.

[Journal Of Alzheimers Disease] Investigators explored the role of Purkinje cell protein 4 in amyloid-β protein precursor processing in Alzheimer’s disease.

[Biomedical Microdevices] Researchers developed a novel microfluidic perfusion 3D cell culture system that overcame the disturbance from air bubbles and intuitionally sets the incubation with the perfusion 3D culture. SH-SY5Y differentiation was examined in static 2D, static 3D, and perfusion 3D cultures.