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Human iPSC-Derived Neural Progenitor Cells Secreting GDNF Provide Protection in Rodent Models of ALS and Retinal Degeneration

[Stem Cell Reports] Neural progenitor cells transduced with glial cell line-derived neurotrophic factors were transplanted into the subretinal space of rats where they protected photoreceptors and vision, the spinal cord of SOD1 rats where they protected motor neurons, and the spinal cord of nude rats where they showed long-term survival and safety.

Bruton Tyrosine Kinase Inhibitors Preserve Anti-CD19 Chimeric Antigen Receptor T-Cell Functionality and Reprogram Tumor Micro-Environment in B-Cell Lymphoma

[Cytotherapy] Researchers revealed that Bruton tyrosine kinase inhibitors (BTKIs) preserved T-cell and CART19 functionality under persistent antigen exposure and further demonstrated that BTKI administration was a potential strategy for mitigating cytokine release syndrome after CART19 treatment.

Safety and Efficacy of Mesenchymal Stromal Cell Therapy for Multi-Drug-Resistant Acute and Late-Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation

[Annals Of Hematology] Scientists presented a multicenter study on the safety and efficacy of MSC therapy for patients with steroid-refractory late steroid-refractory acute graft versus host disease (aGvHD) in comparison to those with aGvHD.

DC Vaccine Enhances CAR-T Cell Antitumor Activity by Overcoming T Cell Exhaustion and Promoting T Cell Infiltration in Solid Tumors

[Clinical And Translational Oncology] Investigators demonstrated that dendritic cell (DC) vaccines could promote CAR-T therapy in solid tumors, which provided the possibility of widespread clinical application of CAR-T cells in the future.

AAV-Mediated Gene Augmentation Therapy of CRB1 Patient-Derived Retinal Organoids Restores the Histological and Transcriptional Retinal Phenotype

[Stem Cell Reports] Crumbs homolog 1 (CRB1) patient-derived PSC were differentiated into CRB1 retinal organoids that showed diminished expression of variant CRB1 protein observed by immunohistochemical analysis.

Organotypic Human Lung Bud Microarrays Identify BMP-Dependent SARS-CoV-2 Infection in Lung Cells

[Stem Cell Reports] Investigators described a high-throughput platform to generate self-organizing and commensurate human lung buds derived from hESCs cultured on micropatterned substrates.

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