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CAR’TCR-T Cells Co-Expressing CD33-CAR and dNPM1-TCR as Superior Dual-Targeting Approach for AML Treatment

[Molecular Therapy Oncology] CAR’TCR-T cells, co-expressing a CD33-CAR and a transgenic dNPM1-TCR, revealed increased and prolonged anti-tumor activity in vitro, particularly in case of low target antigen expression.

Enhanced Bacterial Cancer Therapy Delivering Therapeutic RNA Interference of C-Myc

[Cell & Bioscience] The attenuated tumour targeting Salmonella typhimurium SL7207 strain was modified to carry chromosomally integrated shRNA expression cassettes at the xylA locus.

Engineering Pre-Vascularized 3D Tissue and Rapid Vascular Integration with Host Blood Vessels via Co-Cultured Spheroids-Laden Hydrogel

[Biofabrication] Human adipose-derived stem cells and human umbilical vein cells were prepared as spheroids, which were encapsulated in gelatin methacryloyl hydrogels to fabricate a 3D pre-vascularized tissue.

Optimization of RNAi Efficiency in PVD Neuron of C. elegans

[PLOS One] In order to optimize the RNAi conditions for PVD neuron, scientists fed the worm strains with E. coli HT115 bacteria expressing dsRNA against mec-3, hpo-30, and tiam-1, whose loss of function were known to show dendrite morphology defects in PVD neuron.

Locally Directed Recombinant Adeno-Associated Virus–Mediated IGF-1 Gene Therapy Enhances Osteochondral Repair and Counteracts Early Osteoarthritis In Vivo

[American Journal Of Sports Medicine] Overexpression of insulin-like growth factor 1 (IGF-1) via recombinant adeno-associated viral vectors would improve osteochondral repair and reduce parameters of early perifocal osteoarthrisis in sheep after six months in vivo.

Optimizing the Delivery of mRNA to Mesenchymal Stem Cells for Tissue Engineering Applications

[Molecular Pharmaceutics] Researchers systematically screened a range of nonviral vectors to identify optimal transfection conditions for mRNA delivery to MSCs.

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