Publication

[BMC Biology] Scientists examined the homogeneity and similarity of human-induced pluripotent stem cells (hiPSC) derived neuron (hiPSC-N) and hiPSC derived astrocyte A (hiPSC-A) to their in vivo counterparts, the impact of different lengths of time post Ngn2 induction on hiPSC-N (15 or 21 days), and the impact of hiPSC-N/hiPSC-A co-culture.

[Acta Neuropathologica] Researchers hypothesized that APOEε4 carriers without dementia might carry genetic variations that could protect them from developing APOEε4-mediated Alzheimer's Disease pathology.

[Cell Death & Disease] Investigators found that brain endothelial death receptor 6 (DR6) levels were significantly reduced in a murine model of Alzheimer's disease at the onset of amyloid-β accumulation.

[Cell Death & Disease] The authors investigated the potential involvement of NADH:ubiquinone oxidoreductase core subunit S8 (NDUFS8) in angiogenesis. In HUVECs and other endothelial cell types, they employed viral shRNA to silence NDUFS8 or employed the CRISPR/Cas9 method to knock it out.

[Stem Cell Reports] The authors treated recovered sham and cecal ligation and puncture mice with a mobilizing regimen of granulocyte colony-stimulating factor (G-CSF) at day 20 post-surgery.

[EMBO Reports] Scientists revealed that microcephalin (Mcph1)-knockout mice exhibited congenital macrocytic anemia due to impaired terminal erythroid differentiation during fetal development.