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Epidermal Growth Factor Receptor (EGFR) Is a Target of the Tumor-Suppressor E3 Ligase FBXW7
Investigators uncovered EGFR as substrate of the E3 ubiquitin ligase FBXW7 and found multiple phosphodegron-like motifs within its intracellular domain that when mutated reduce EGFR degradation.They used CRISPR base editors to...
Newsletters
OrgaSegment: Deep-Learning Based Organoid Segmentation to Quantify CFTR Dependent Fluid Secretion
Investigators presented OrgaSegment, a MASK-RCNN based deep-learning segmentation model allowing for the segmentation of individual intestinal patient-derived organoids structures from bright-field images.
Endothelial Cell News
Dapagliflozin Promotes White Adipose Tissue Browning through Regulating Angiogenesis in High Fat Induced Obese Mice
Scientists explored the role of dapagliflozin on WAT browning in high-fat diet (HFD)-induced obese mice. Male C57BL/6J mice were used to establish an obesity model by following feeding with HFD for...
Endothelial Cell News
SOX17/ETV2 Improves the Direct Reprogramming of Adult Fibroblasts to Endothelial Cells
Investigators directly reprogrammed adult human dermal fibroblasts into reprogrammed endothelial cells (ECs) by overexpressing SOX17 in conjunction with ETS variant 2 (ETV2).
Endothelial Cell News
Autophagy Induced by Low Shear Stress Leads to Endothelial Glycocalyx Disruption
Human umbilical vein endothelial cells were subjected to physiological shear stress and low shear stress treatments, followed by the application of autophagy inducers and inhibitors. Additionally, cells were treated with specific...
Human Immunology News
Human Platelet Lysate Enhances In Vivo Activity of CAR-Vδ2 T Cells by Reducing Cellular Senescence and Apoptosis
Scientists sought to enhance the in vivo longevity of CAR-Vδ2 T cells by modulating ex vivo manufacturing conditions and selecting an optimal CAR costimulatory domain.