Publication

[Molecular Therapy] Using the humanized bone marrow/liver/thymus mouse model and nonhuman primate model of HIV infection, scientists evaluated two CAR-based gene therapy approaches.

[Molecular Therapy Oncology] Investigators developed a CAR T cell therapy targeting prostate stem cell antigen for prostate and pancreatic cancers, showing improved pre-clinical antitumor activity and T cell persistence by optimizing the intracellular co-stimulatory domain.

[Haematologica] Scientists evaluated patients with relapsed multiple myeloma with renal impairment treated with standard of care idecabtagene vicleucel, as outcomes with CAR T cell therapy are unknown in this population.

[Stem Cell Reports] The authors explored the impact of MSCs on the differentiation of hematopoietic stem/progenitor cells and progenitors through the C-C motif chemokine CCL2/CCR2 signaling pathway.

[Molecular Therapy] Single-cell RNA sequencing with in vivo lineage tracing in non-alcoholic steatohepatitismodel mice reveals a subpopulation of HSCs transitioning back to a state resembling their developmental precursors, mesothelial cells, after liver injury.

[Molecular Therapy-Methods & Clinical Development] Using a trans-vessel wall device, investigators delivered chemically modified mRNAs and mRNA-enhanced mesenchymal stromal cells expressing Vascular Endothelial Growth Factor A directly to the heart.