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Cell Therapy News
LNP-RNA-Engineered Adipose Stem Cells for Accelerated Diabetic Wound Healing
[Nature Communications] The authors conceived a series of lipid nanoparticles to reprogram sdipose stem cells with durable protein secretion capacity for enhanced tissue engineering and regeneration
Cell Therapy News
RNA Origami Functions as a Self-Adjuvanted Nanovaccine Platform for Cancer Immunotherapy
[ACS Nano] Scientists demonstrated that the assembled RNA-OG-peptide nanovaccines induced dendritic cell maturation, reduced tumor-mediated immunosuppression, and mobilized tumor-specific CD8+ T cell responses at the tumor site.
Mammary Cell News
The Breast Cancer Coagulome in the Tumor Microenvironment and Its Role in Prognosis and Treatment Response to Chemotherapy
[Journal Of Thrombosis And Haemostasis] Researchers investigated the breast tumor coagulome and its relation to prognosis, treatment response to chemotherapy, and the tumor microenvironment.
Mammary Cell News
HDAC Inhibitors Target IRS4 to Enhance Anti-AR Therapy in AR-Positive Triple-Negative Breast Cancer
[International Journal Of Oncology] A combination of an androgen receptor (AR) inhibitor and a selective histone deacetylase inhibitor was used to treat AR‑positive TNBC cell lines, and a synergistic effect of these drugs was observed.
Mammary Cell News
Conditional In Vivo Deletion of LYN Kinase Has Little Effect on a BRCA1 Loss-of-Function-Associated Mammary Tumor Model
[Disease Models & Mechanisms] The authors examined the interaction between LYN kinase and BRCA1 loss-of-function in an in vivo mouse mammary tumor model, using conditional knockout Brca1 and Lyn alleles.
Mammary Cell News
Investigation of Co-Treatment Multi-Targeting Approaches in Breast Cancer Cell Lines
[European Journal Of Pharmacology] Investigators evaluated different treatment approaches in breast cancer cells. The expression of some membrane markers relevant to resistance was assessed.