Publication

[Scientific Reports] Scientists confirmed the observed underexpression of miRNA-410 in glioma tissues and several glioma cells by Quantitative RT-PCR. Their findings suggested that epigenetic alterations occurring at the promoter region of miR-410 may be responsible for the reduced expression of miR-410 in glioma.

[Translational Psychiatry] To study mechanisms of pathogenesis for GATA zinc finger domain containing 2B (GAND), scientists characterized a mouse model harboring an inactivating mutation in Gatad2b. Homozygous Gatad2bmutants died perinatally, while haploinsufficient Gatad2b mice exhibited behavioral abnormalities resembling the clinical features of GAND patients.

[Cell Death & Disease] Scientists investigated the impact of non-alcoholic fatty liver disease on breast cancer tumor growth and cell viability through the potential mediator, hepatic fibroblast growth factor 21.

[Nature Communications] The authors showed that Xenopus laevis embryos were much more sensitive to a diverse set of chemical and molecular-biological perturbations when allowed to develop alone or in small groups, than in large groups.

[Nature Medicine] Investigators conducted a Phase I/II trial of cord blood-derived natural killer cells expressing anti-CD19 chimeric antigen receptor and interleukin-15 in 37 patients with CD19+ B cell malignancies.

[Bone Marrow Transplantation] Scientists retrospectively analyzed clinical data of 1603 patients who received single-unit cord blood transplantation in eight institutes in Japan between 2000 and 2017. Each HLA allele was categorized into 19 supertypes, and the prognostic effect of disparities was then assessed.