Publication

[Cell Stem Cell] Scientists performed a genome-wide CRISPR activation screening using a human mesenchymal precursor cell model of the progeroid syndrome.

[ACS Applied Materials & Interfaces] By means of a “live-cell” template strategy, silica replicas displaying the same morphology and topography of the mammalian cells used as templates were fabricated.

[Stem Cell Reports] Longitudinal RNA sequencing analyses identified the continuous induction of many RNA splicing regulators. Among these, the knockdown of RBFOX3, significantly abrogated the transdifferentiation.

[Nature Medicine] Investigators showed that there was selective loss of synaptic connections between the cortex and striatum in postmortem tissue from patients with Huntington’s disease that is associated with the increased activation and localization of complement proteins, innate immune molecules, to these synaptic elements.

[Nature Communications] Researchers introduced a different method to acquire snapshots of single-cell cortical activity maps from freely-moving mice using a calcium sensor called CaMPARI.

[Molecular Psychiatry] Scientists showed that TCF7L2, which is a key transcriptional effector of the Wnt/β-catenin pathway, played a cell-autonomous role in postnatal astrocyte maturation and impacted adult social behavior.