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Regulation of Young-Adult Neurogenesis and Neuronal Differentiation by Neural Cell Adhesion Molecule 2 (NCAM2)

[Cerebral Cortex] The authors analyzed the functions of NCAM2 in the regulation of radial glial progenitors in adult neurogenesis and during corticogenesis and characterized the presence of NCAM2 across the main cell types of the neurogenic process in the dentate gyrus.

Brain Oxidative Stress Mediates Anxiety-Like Behavior Induced by Indomethacin in Zebrafish: Protective Effect of Alpha-Tocopherol

[Naunyn-Schmiedebergs Archives Of Pharmacology] Zebrafish were utilized as experimental model and subdivided into control, Indomethacin (INDO) 1 mg/Kg, INDO 2 mg/Kg, INDO 3 g/Kg, α-TP 2 mg/Kg, α-TP 2 mg/Kg + INDO 1 mg/Kg and α-TP + INDO 2 mg/Kg groups.

DMRT1 Regulates Human Germline Commitment

[Nature Cell Biology] Investigators followed the progression of nascent primordial germ cell-like cells derived from human ESCs in vitro.

Monolayer Platform to Generate and Purify Primordial Germ-Like Cells In Vitro Provides Insights into Human Germline Specification

[Nature Communications] The authors developed a simplified, monolayer method to differentiate hPSCs into primordial germ cells within three and a half days.

The COPD GWAS Gene ADGRG6 Instructs Function and Injury Response in Human iPSC-Derived Type II Alveolar Epithelial Cells

[American Journal of Human Genetics] Researchers applied an inducible CRISPR interference human induced pluripotent stem cells platform to explore ADGRG6 function in iPSC-derived human type 2 alveolar epithelial cells.

Derivation of Naïve Human Embryonic Stem Cells Using a CHK1 Inhibitor

[Stem Cell Reviews and Reports] Investigators showed that exposure of frozen human blastocysts to an inhibitor of checkpoint kinase 1 (CHK1) upon thaw greatly enhanced establishment of karyotypically normal late naïve human ESC cultures.

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