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Hepatic Cell News
PGD2/DP1 Axis Promotes Liver Regeneration by Secreting Wnt2 in Kupffer Cells in Mice
[Hepatology] Two-thirds partial hepatectomy, massive hepatectomy, and carbon tetrachloride-induced chronic injury were performed in mice to study the mechanisms of live regeneration.
Newsletters
Clinical Implications of Wnt Pathway Genetic Alterations in Men with Advanced Prostate Cancer
[Prostate Cancer and Prostatic Diseases] Investigators utilized the Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort clinical-genomic database for this retrospective analysis.
Newsletters
Targeting Valine Catabolism to Inhibit Metabolic Reprogramming in Prostate Cancer
[Cell Death & Disease] Through the suppression of branched-chain amino acid (BCAA) availability, researchers reported significantly reduced lipid content, strongly indicating that BCAAs were important lipogenic fuels in prostate cancer.
Newsletters
Embryonic Microenvironment Suppresses YY1 and YY1-Related Genes in Prostate Cancer Stem Cells
[Pathology - Research and Practice] To investigate the embryonic microenvironment impact on Yin yang 1 (YY1) expression in CSC populations, firstly cancer stem cells (CSCs) were microinjected into the inner cell mass of blastocysts and then prostate CSCs were co-cultured with blastocysts.
Newsletters
A Novel Prognostic Model of De Novo Metastatic Hormone-Sensitive Prostate Cancer to Optimize Treatment Intensity
[International Journal of Clinical Oncology] 1092 Japanese patients diagnosed with de novo metastatic hormone-sensitive prostate cancer between 2014 and 2020 were registered. The patients treated with androgen deprivation therapy and first-generation anti-androgens were assigned to the discovery or validation cohorts.
Newsletters
The PP2A Regulator IER5L Supports Prostate Cancer Progression
[Cell Death & Disease] The authors showed that the less studied member of the Immediate Early Response (IER) family, IER 5 like (IER5L), was upregulated in aggressive prostate cancer.