Publication

[Cell Death & Differentiation] Investigators found brain specific deletion of Pd1 results in abnormal cortical neurogenesis, including enhanced proliferation of neural progenitors and reduced neuronal differentiation.

[Cell Death & Disease] Scientists discovered severe neurogenic deficits and hippocampal-based spatial memory defects accompanied by increased neuroblast death and high loss of newly formed neurons in Kidins220 deficient mice.

[npj Parkinson's Disease] Investigators used imaging mass cytometry to overcome challenges in understanding the contribution of mitochondrial dysfunction to Parkinson’s disease pathogenesis, measuring multiple protein targets, whilst retaining the spatial relationship between targets in post-mortem midbrain sections.

[Molecular Neurobiology] Using human pluripotent stem cell–derived cortical neurons, single-cell calcium imaging, and electrophysiological recording, scientists showed that transient receptor potential canonical-6 (TRPC6) knockout reduced store-operated calcium entry signaling and leads to hyperexcitability of neurons by increasing action potential frequency and network burst frequency.

[Scientific Reports] Researchers demonstrated that menstrual stromal cells-derived planar presenilin 1 (PSEN 1) I416T cholinergic-like cells and cerebral spheroids reproduced the typical neuropathological markers of familial Alzheimer’s disease in 4 post-transdifferentiating or 11 days of transdifferentiating, respectively.

[Scientific Reports] Scientists tested whether astrocytes-neuron lactate shuttle activation could be another potential underpinning mechanism that complements collateral flow in the protection process.