Deletion of TRPC6, an Autism Risk Gene, Induces Hyperexcitability in Cortical Neurons Derived from Human Pluripotent Stem Cells

Using human pluripotent stem cell–derived cortical neurons, single-cell calcium imaging, and electrophysiological recording, scientists showed that transient receptor potential canonical-6 (TRPC6) knockout reduced store-operated calcium entry signaling and leads to hyperexcitability of neurons by increasing action potential frequency and network burst frequency.