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PARP Inhibitors for Breast Cancer Treatment

[Jama Oncology] The authors summarize the biological rationale behind the use of poly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors in breast cancer, as well as the available evidence, recent progress, and potential future applications of these agents.

Lung Repair and Regeneration: Advanced Models and Insights into Human Disease

[Cell Stem Cell] Scientists summarize recent research on the cellular complexity of the mammalian respiratory system with a focus on gas exchange and immunological defense functions of the lung.

State-of-the-Art in Transposable Element Modulation Affected by Drugs in Malignant Prostatic Cancer Cells

[Journal of Cellular Biochemistry] The authors focus on prostate carcinoma cell lines and offer a comprehensive review intended to scrutinize the associations and interactions between transposable elements and genes.

Claudin 18.2 as a Novel Therapeutic Target

[Nature Reviews Clinical Oncology] Scientists highlight the biological rationale and explore the clinical activity of therapies that target claudin 18.2 in patients with advanced-stage gastric cancer and explore the potential for expansion of claudin 18.2-targeted therapies to patients with other claudin 18.2-positive solid tumours.

The Movement of Mitochondria in Breast Cancer: Internal Motility and Intercellular Transfer of Mitochondria

[Clinical & Experimental Metastasis] The authors focus on the effect of mitochondria movement on breast cancer progression.

Revolutionizing Pancreatic Islet Organoid Transplants: Improving Engraftment and Exploring Future Frontiers

The authors focus on strategies enhancing the in vivo engraftment of islet organoids, namely vascularization, encapsulation, immune evasion, alternative extra-hepatic transplant sites, and 3D bioprinting.

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