Publication

[Heliyon] Scientists showed that oncogenic aurora kinase A promoted breast cancer-related RNA aberrant splicing in a context-dependent manner.

[Nature Communications] Researchers presented a uniquely large dataset screening over 5000 targeted agent combinations across 81 NSCLC lines. Their analysis revealed a profound heterogeneity of response across the tumor models.

[Cell Death & Disease] Scientists reported a small-molecule inhibitor of OTUD3 (OTUDin3) by computer-aided virtual screening and biological experimental verification. OTUDin3 exhibited pronounced antiproliferative and proapoptotic effects by inhibiting deubiquitinating activity of OTUD3 in NSCLC cell lines.

[Scientific Reports] Investigators explored the potential therapeutic effects and molecular mechanisms of amifostine on bleomycin (BLM)-induced pulmonary fibrosis in mice. A mouse model of pulmonary fibrosis was established using BLM.

[Cell Biology International] Scientists found that follistatin-like 1 (FSTL1) expression was upregulated in the lung tissues of patients with idiopathic pulmonary fibrosis and that SENP1 was overexpressed in senescent alveolar epithelial cells.

[Cell Death Discovery] Associations with clinicopathologic features, survival, and the prognostic value of miR-375 in lung squamous cell carcinoma (LUSC) were clarified in a retrospective study of 90 pairs of LUSC tissues. In vitro and in vivo gain- and loss-of-function assays were conducted to validate the effects and mechanism of miR-375 in LUSC.